Actoplus Met XR and Collagenase clostridium histolyticum

• Generic Name: metformin / pioglitazone
• Dosage Forms: tablet, film coated, extended release
• Other Brand Names: Actoplus Met, Actoplus Met XR

Actoplus Met XR is a combination of two oral diabetes medicines that help control blood sugar levels.

Actoplus Met XR is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus who do not use daily insulin injections. This medicine is not for treating type 1 diabetes.

Actoplus Met XR may also be used for purposes not listed in this medication guide.

• Generic Name: collagenase clostridium histolyticum
• Dosage Forms: n.a.
• Other Brand Names: Xiaflex

Collagenase clostridium histolyticum is made from a mixture of proteins derived from a certain bacteria.

Collagenase clostridium histolyticum is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.

Collagenase clostridium histolyticum is also used to treat a related condition called Peyronie's disease in adult men. This condition causes scar tissue or "plaque" to develop under the skin of the penis, resulting in an abnormal curving of the penis during erection.

Collagenase clostridium histolyticum is available for Peyronie's disease only from a certified pharmacy under a special program called Xiaflex REMS. You must be registered in the program and understand the risks of taking collagenase clostridium histolyticum.

Collagenase clostridium histolyticum may also be used for purposes not listed in this medication guide.