Actoplus Met XR and Pitolisant

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with pitolisant may increase plasma concentrations of substrates of the hepatic and intestinal uptake transporter, organic cation transporter 1 (OCT1). Pitolisant has demonstrated inhibitory potential towards OCT1 in vitro. The clinical significance of this effect has not been established. MANAGEMENT: Caution is recommended when pitolisant is administered with OCT1 substrates. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

MONITOR: Coadministration with pitolisant may increase plasma concentrations of substrates of the hepatic and intestinal uptake transporter, organic cation transporter 1 (OCT1). Pitolisant has demonstrated inhibitory potential towards OCT1 in vitro. The clinical significance of this effect has not been established.

MANAGEMENT: Caution is recommended when pitolisant is administered with OCT1 substrates.

Actoplus Met XR

Generic Name: metformin / pioglitazone

Brand name: Actoplus Met, Actoplus Met XR

Synonyms: n.a.

What is Actoplus Met XR?

Pitolisant

Generic Name: pitolisant

Brand name: Wakix

Synonyms: n.a.

What is Pitolisant?