Actoplus Met XR and Verapamil Injection
Determining the interaction of Actoplus Met XR and Verapamil Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Verapamil may decrease the effects of metFORMIN. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Verapamil may decrease the glucose-lowering effects of metformin. The mechanism may involve verapamil inhibition of the organic cation transporter 1 (OCT1), thereby inhibiting hepatic uptake of metformin. In 12 healthy male subjects, sustained-release verapamil (180 mg a day for 3 days) significantly decreased the glucose-lowering effects of immediate-release metformin (1000 mg in the evening, 750 mg the following morning), as evidenced by a reduction in maximum blood glucose concentrations and the area under the glucose concentration-time curve by 62.5% and 238%, respectively.
MANAGEMENT: Caution is advised if verapamil and metformin are used concomitantly. Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosages may be adjusted as necessary.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cho SK, Kim CO, Park ES, Chung JY "Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers." Br J Clin Pharmacol 78 (2014): 1426-32
Generic Name: metformin / pioglitazone
Brand name: Actoplus Met, Actoplus Met XR
Synonyms: n.a.
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Actoplus Met XR-Verapamil Intravenous
- Actoplus Met XR-Verapamil Long-Acting Capsules
- Actoplus Met XR-Verapamil Long-Acting Tablets
- Actoplus Met XR-Verapamil oral/injection
- Actoplus Met XR-Verapamil Sustained-Release Capsules
- Actoplus Met XR-Verdeso
- Verapamil Injection-Actos
- Verapamil Injection-Acuflex
- Verapamil Injection-Acular
- Verapamil Injection-Acular eent
- Verapamil Injection-Acular LS
- Verapamil Injection-Acular PF