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Actos and Isavuconazonium Intravenous

Determining the interaction of Actos and Isavuconazonium Intravenous and the possibility of their joint administration.

Check result:

Actos <> Isavuconazonium Intravenous

Relevance: 12.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using isavuconazonium together with pioglitazone can alter the blood levels and effects of both medications. Specifically, isavuconazonium levels may decrease, which may make the medication less effective. At the same time, pioglitazone levels may increase. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of isavuconazonium sulfate (prodrug of isavuconazole), a substrate as well as a moderate inhibitor of CYP450 3A4/5, with drugs that are both a substrate as well as inducer of CYP450 3A4/5 may result in decreased plasma concentrations of isavuconazole and increased plasma concentrations of the other drug. Isavuconazole may inhibit the metabolism of the coadministered drug while its own metabolism may be induced by the coadministered drug.

MANAGEMENT: Caution is advised if isavuconazonium sulfate is used concomitantly with drugs that are both a substrate and inducer of CYP450 3A4/5, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever these drugs are added to or withdrawn from combination therapy.

References

"Product Information. Emend (aprepitant)." Merck & Company Inc, West Point, PA.
"Product Information. Cresemba (isavuconazonium)." Astellas Pharma US, Inc, Deerfield, IL.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Emend for Injection (fosaprepitant)." Merck & Company Inc, West Point, PA.

Actos

Generic Name: pioglitazone

Brand name: Actos

Synonyms: n.a.

What is Actos?

Isavuconazonium Intravenous

Generic Name: isavuconazonium

Brand name: Cresemba

Synonyms: Isavuconazonium, Isavuconazonium Sulfate

What is Isavuconazonium Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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