Actos and Qudexy XR

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with topiramate may slightly reduce exposure to certain antidiabetic agents, such as pioglitazone and glyburide and their active metabolites. The mechanism for this interaction has not been delineated. In a clinical study, topiramate decreased the AUC of pioglitazone by 15%, but did not alter Cmax. In addition, topiramate reduced the Cmax and AUC of the active hydroxy-metabolite by 13% and 16%, respectively, as well as a 60% decrease in Cmax and AUC of the active keto-metabolite. The clinical significance of these findings is unknown. In another study, Cmax and AUC of glyburide were reduced by 22% and 25%, respectively, during concomitant topiramate administration. In addition, the AUC of the two active metabolites were also reduced by 13% and 15%, and Cmax was reduced by 18% and 25%, respectively. MANAGEMENT: Although these changes in exposure to pioglitazone and glyburide may not be clinically important, careful monitoring of glycemic control is recommended during concomitant therapy with topiramate. References Manitpisitkul P, Curtin CR, Shalayda K, Wang SS, Ford L, Heald D "Pharmacokinetic interactions between topiramate and pioglitazone and metformin." Epilepsy Res 108 (2014): 1519-32 "Product Information. Topamax (topiramate)." Ortho Pharmaceutical Corporation, Raritan, NJ. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Topiramate (topiramate)." Cipla USA Inc., Miami, FL. Cerner Multum, Inc. "Australian Product Information." O 0 View all 5 references

MONITOR: Coadministration with topiramate may slightly reduce exposure to certain antidiabetic agents, such as pioglitazone and glyburide and their active metabolites. The mechanism for this interaction has not been delineated. In a clinical study, topiramate decreased the AUC of pioglitazone by 15%, but did not alter Cmax. In addition, topiramate reduced the Cmax and AUC of the active hydroxy-metabolite by 13% and 16%, respectively, as well as a 60% decrease in Cmax and AUC of the active keto-metabolite. The clinical significance of these findings is unknown. In another study, Cmax and AUC of glyburide were reduced by 22% and 25%, respectively, during concomitant topiramate administration. In addition, the AUC of the two active metabolites were also reduced by 13% and 15%, and Cmax was reduced by 18% and 25%, respectively.

MANAGEMENT: Although these changes in exposure to pioglitazone and glyburide may not be clinically important, careful monitoring of glycemic control is recommended during concomitant therapy with topiramate.

Actos

Generic Name: pioglitazone

Brand name: Actos

Synonyms: n.a.

What is Actos?

Qudexy XR

Generic Name: topiramate

Brand name: Qudexy XR Sprinkle, Topamax, Topamax Sprinkle, Trokendi XR, Qudexy XR, Topiragen

Synonyms: Qudexy XR Sprinkle, Qudexy XR Capsules

What is Qudexy XR?