Drug search by name

Acunivive 90 Injection System and Alimta

Determining the interaction of Acunivive 90 Injection System and Alimta and the possibility of their joint administration.

Check result:

Acunivive 90 Injection System <> Alimta

Relevance: 11.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using PEMEtrexed together with ketorolac may increase the effects of PEMEtrexed. Contact your doctor if you experience fever, chills, body aches, flu symptoms, mouth sores or white patches, and severe diarrhea. PEMEtrexed can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Coadministration with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the plasma concentrations of pemetrexed. The mechanism has not been described but may be related to NSAID inhibition of renal prostaglandins. Use of NSAIDs has been associated with nephropathy manifested as elevations in serum creatinine and BUN, tubular necrosis, glomerulitis, renal papillary necrosis, acute interstitial nephritis, nephrotic syndrome, and renal failure. Since pemetrexed is primarily eliminated unchanged by renal excretion, coadministration with NSAIDs may result in delayed and/or decreased clearance. Daily ibuprofen dosage of 400 mg four times a day has been shown to reduce pemetrexed clearance by about 20% in patients with normal renal function, whereas aspirin at 325 mg every 6 hours did not. The effect of higher dosages of ibuprofen or aspirin is unknown.

MANAGEMENT: Ibuprofen at 400 mg and aspirin at 325 mg four times a day, or less, may be used with pemetrexed in patients with normal renal function. However, caution is advised in patients with mild to moderate renal insufficiency (creatinine clearance 45 to 79 mL/min). These patients should avoid taking NSAIDs with short elimination half-lives (e.g., diclofenac, etodolac, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, sulindac, tolmetin, low dosages of salicylates) 2 days before to 2 days after pemetrexed administration. If concomitant administration is necessary, patients should be monitored closely for toxicity, especially myelosuppression, nephrotoxicity, and gastrointestinal toxicity. In the absence of data regarding use with NSAIDs with longer half-lives, withholding NSAID dosing for at least 5 days before to 2 days after pemetrexed administration is recommended.

References

Shand DG, Epstein C, Kinberg-Calhoun J, et al "The effect of etodolac administration on renal function in patients with arthritis." J Clin Pharmacol 26 (1986): 269-74
Lomvardias S, Pinn VW, Wadhwa ML, et al "Nephrotic syndrome associated with sulindac." N Engl J Med 304 (1981): 424
Tietjen DP "Recurrence and specificity of nephrotic syndrome due to tolmetin." Am J Med 87 (1989): 354-5
Turner GA, Walker RJ, Bailey RR, et al "Sulindac-induced acute interstitial nephritis." N Z Med J 97 (1984): 239-40
Chan XM "Fatal renal failure due to indomethacin." Lancet 2 (1987): 340
Sarma PS "Fatal acute renal failure after piroxicam." Clin Nephrol 31 (1989): 54
Fellner SK "Piroxicam-induced acute interstitial nephritis and minimal-change nephrotic syndrome." Am J Nephrol 5 (1985): 142-3
McCarthy JT, Torres VE, Romero JC, et al "Acute intrinsic renal failure induced by indomethacin." Mayo Clin Proc 57 (1982): 289-96
"Product Information. Celebrex (celecoxib)." Searle, Chicago, IL.
Quan DJ, Kayser SR "Ketorolac induced acute renal failure following a single dose." J Toxicol Clin Toxicol 32 (1994): 305-9
Pazmino PA, Pazmino PB "Ketoprofen-induced irreversible renal failure." Nephron 50 (1988): 70-1
Frais MA, Burgess ED, Mitchell LB "Piroxicam-induced renal failure and hyperkalemia." Ann Intern Med 99 (1983): 129-30
Perneger TV, Whelton PK, Klag MJ "Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs." N Engl J Med 331 (1994): 1675-9
Feldman HI, Kinman JL, Berlin JA, et al. "Parenteral ketorolac: the risk for acute renal failure." Ann Intern Med 126 (1997): 193-9
van Biljon G "Reversible renal failure associated with ibuprofen in a child. A case report." S Afr Med J 76 (1989): 34-5
Tattersall J, Greenwood R, Farrington K "Membranous nephropathy associated with diclofenac ." Postgrad Med J 68 (1992): 392-3
Gerber D "Adverse reactions of piroxicam." Drug Intell Clin Pharm 21 (1987): 707-10
Mitnick PD, Klein WJ, Jr "Piroxicam-induced renal disease." Arch Intern Med 144 (1984): 63-4
Morgenstern SJ, Bruns FJ, Fraley DS, et al "Ibuprofen-associated lipoid nephrosis without interstitial nephritis." Am J Kidney Dis 14 (1989): 50-2
Carmichael J, Shankel SW "Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function." Am J Med 78 (1985): 992-1000
Curt GA, Kaldany A, Whitley LG, et al "Reversible rapidly progressive renal failure with nephrotic syndrome due to fenoprofen calcium." Ann Intern Med 92 (1980): 72-3
Pearce CJ, Gonzalez FM, Wallin JD "Renal failure and hyperkalemia associated with ketorolac tromethamine." Arch Intern Med 153 (1993): 1000-2
Radford RG, Holley KE, Grande JP, Larson TS, Wagoner RD, Donadio JV, Mccarthy JT "Reversible membranous nephropathy associated with the use of nonsteroidal anti-inflammatory drugs." JAMA 276 (1996): 466-9
Hannedouche T, Dehaine V, Noel LH, Jungers P "Acute tubular necrosis associated with acute pyelonephritis and concomitant diclofenac therapy ." Clin Nephrol 28 (1987): 103-4
de Crespigny PJ, Becker GJ, Ihle BU, et al "Renal failure and nephrotic syndrome associated with sulindac." Clin Nephrol 30 (1988): 52-5
Reeve PA, Moshiri M, Bell GD "Pulmonary oedema, jaundice and renal impairment with naproxen." Br J Rheumatol 26 (1987): 70-1
Aitken HA, Burns JW, McArdle CS, Kenny GNC "Effects of ketorolac trometamol on renal function." Br J Anaesth 68 (1992): 481-5
Schwartz J, Altshuler E, Madjar J, Habot B "Acute renal failure associated with diclofenac treatment in an elderly woman ." J Am Geriatr Soc 36 (1988): 482
"Product Information. Alimta (pemetrexed)." Lilly, Eli and Company, Indianapolis, IN.
Shah GM, Muhalwas KK, Winer RL "Renal papillary necrosis due to ibuprofen." Arthritis Rheum 24 (1981): 1208-10
Artinano M, Etheridge WB, Stroehlein KB, Barcenas CG "Progression of minimal-change glomerulopathy to focal glomerulosclerosis in a patient with fenoprofen nephropathy." Am J Nephrol 6 (1986): 353-7
Fong HJ, Cohen AH "Ibuprofen-induced acute renal failure with acute tubular necrosis." Am J Nephrol 2 (1982): 28-31
Katz SM, Capaldo R, Everts EA, DiGregorio JG "Tolmetin: association with reversible renal failure and acute interstitial nephritis." JAMA 246 (1981): 243-5
Jick H, Derby LE, Garcia Rodriguez LA, Jick SS, Dean AD "Nonsteroidal antiinflammatory drugs and certain rare, serious adverse events: a cohort study." Pharmacotherapy 13 (1993): 212-7
Kelley M, Bastani B "Ketorolac-induced acute renal failure and hyperkalemia." Clin Nephrol 44 (1995): 276-7
Colome Nafria E, Solans R, Espinach J, Delgadillo J, Fonollosa V "Renal papillary necrosis induced by flurbiprofen ." DICP 25 (1991): 870-1
Blackshear JL, Davidman M, Stillman MT "Identification of risk for renal insufficiency from nonsteroidal anti-inflammatory drugs." Arch Intern Med 143 (1983): 1130-4
Kimberly RP, Plotz PH "Aspirin-induced depression of renal function." N Engl J Med 296 (1977): 418-24
Delmas PD "Non-steroidal anti-inflammatory drugs and renal function." Br J Rheumatol 34 Suppl (1995): 25-8
Maher JF "Analgesic nephropathy. Observations, interpretations, and perspective on the low incidence in America." Am J Med 76 (1984): 345-8
Feldman HI, Kinman JL, Strom BL "Acute renal failure and ketorolac." Ann Intern Med 127 (1997): 493-4
Boiskin I, Saven A, Mendez M, Raja RM "Indomethacin and the nephrotic syndrome." Ann Intern Med 106 (1987): 776-7
Murray MD, Greene PK, Brater DC, et al "Effects of flurbiprofen on renal function in patients with moderate renal insufficiency." Br J Clin Pharmacol 33 (1992): 385-93
Whelton A "Renal effects of over-the-counter analgesics." J Clin Pharmacol 35 (1995): 454-63
Bonney SL, Northington RS, Hedrich DA, Walker BR "Renal safety of two analgesics used over the counter: ibuprofen and aspirin." Clin Pharmacol Ther 40 (1986): 373-7
Wellborne FR, Claypool RG, Copley JB "Nephrotic range pseudoproteinuria in a tolmetin-treated patient." Clin Nephrol 19 (1983): 211-2
Marasco WA, Gikas PW, Azziz-Baumgartner R, et al "Ibuprofen-associated renal dysfunction: pathophysiologic mechanisms of acute renal failure, hyperkalemia, tubular necrosis, and proteinuria." Arch Intern Med 147 (1987): 2107-16
Moss AH, Riley R, Murgo A, Skaff LA "Over-the-counter ibuprofen and nephrotic syndrome." Ann Intern Med 105 (1986): 303
Zawada ET "Renal consequences of nonsteroidal antiinflammatory drugs." Postgrad Med J 71 (1982): 223-30
Beun GD, Leunissen KM, Van Breda Vriesman PJ, Van Hooff JP, Grave W "Isolated minimal change nephropathy associated with diclofenac." Br Med J (Clin Res Ed) 295 (1987): 182-3
Buck ML, Norwood VF "Ketorolac-induced acute renal failure in a previously healthy adolescent." Pediatrics 98 (1996): 294-6
Whelton A, Bender W, Vaghaiwalla F, et al "Sulindac and renal impairment." JAMA 249 (1983): 2892-3
Rossi E, Ferraccioli GF, Cavalieri F, Menta R, Dall'Aglio PP, Migone L "Diclofenac-associated acute renal failure. Report of 2 cases." Nephron 40 (1985): 491-3
Riegger GA, Kahles HW, Elsner D, Kromer EP, Kochsiek K "Effects of acetylsalicylic acid on renal function in patients with chronic heart failure." Am J Med 90 (1991): 571-5
Schwarz A, Krause PH, Keller F, et al "Granulomatous interstitial nephritis after nonsteroidal anti-inflammatory drugs." Am J Nephrol 8 (1988): 410-6
Wolf G, Porth J, Stahl RA "Acute renal failure associated with rofecoxib." Ann Intern Med 133 (2000): 394
Perazella MA, Buller GK "Can ibuprofen cause acute renal failure in a normal individual? A case of acute overdose." Am J Kidney Dis 18 (1991): 600-2
Turner R "Hepatic and renal tolerability of long-term naproxen treatment in patients with rheumatoid arthritis." Semin Arthritis Rheum 17 (1988): 29-35
Loeffler M, Hanson G, Philp T "Piroxicam-induced renal failure following relief of chronic retention." Br J Urol 63 (1989): 438-9
Haragsim L, Dalal R, Bagga H, Bastani B "Ketorolac-induced acute renal failure and hyperkalemia: report of three cases." Am J Kidney Dis 24 (1994): 578-80
Ling BN, Bourke E, Campbell WG, Delaney VB "Naproxen-induced nephropathy in systemic lupus erythematosus." Nephron 54 (1990): 249-55
Berg KJ, Talseth T "Acute renal effects of sulindac and indomethacin in chronic renal failure." Clin Pharmacol Ther 37 (1985): 447-52
Shpilberg O, Douer D, Ehrenfeld M, et al "Naproxen-associated fatal acute renal failure in multiple myeloma." Nephron 55 (1990): 448-9
Mitnick PD, Greenberg A, DeOreo PB, Weiner BM, Coffman TM, Walker BR, Agus ZS, Goldfarb S "Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney." Clin Pharmacol Ther 28 (1980): 680-9
Feinfeld DA, Olesnicky L, Pirani CL, Appel GB "Nephrotic syndrome associated with use of the nonsteroidal anti-inflammatory drugs: case report and review of the literature." Nephron 37 (1984): 174-9
Segasothy M, Chin GL, Sia KK, Zulfiqar A, Samad SA "Chronic nephrotoxicity of anti-inflammatory drugs used in the treatment of arthritis." Br J Rheumatol 34 (1995): 162-5
Gary NE, Dodelson R, Eisinger RP "Indomethacin-associated acute renal failure." Am J Med 69 (1980): 135-6
Jonsson CE, Ericsson F "Impairment of renal function after treatment of a burn patient with diclofenac, a non-steroidal anti-inflammatory drug." Burns 21 (1995): 471-3
Cangiano JL, Figueroa J, Palmer R "Renal hemodynamic effects of nabumetone, sulindac, and placebo in patients with osteoarthritis." Clin Ther 21 (1999): 503-12
Ogawa M, Ueda S, Hamano Y, Ito K, Saisho H, Akikusa B "Membranous nephropathy associated with oxaprozin treatment." Nephron 74 (1996): 439-40
Caruana RJ, Semble EL "Renal papillary necrosis due to naproxen." J Rheumatol 11 (1984): 90-1
Chatterjee GP "Nephrotic syndrome induced by tolmetin." JAMA 246 (1981): 1589
Wendland ML, Wagoner RD, Holley KE "Renal failure associated with fenoprofen." Mayo Clin Proc 55 (1980): 103-7
Watson WA, Freer JP, Katz RS, Basch C "Kidney function during naproxen therapy in patients at risk for renal insufficiency." Semin Arthritis Rheum 17 (1988): 12-6
Wong F, Massie D, Hsu P, Dudley F "Indomethacin-induced renal dysfunction in patients with well- compensated cirrhosis." Gastroenterology 104 (1993): 869-76
Buller GK, Perazella MA "Acute renal failure and ketorolac." Ann Intern Med 127 (1997): 493
Brater DC, Anderson SA, Brown D "Reversible acute decrease in renal function by NSAIDs in cirrhosis." Am J Med Sci 294 (1987): 168-74
Kaufhold J, Wilkowski M, McCabe K "Flurbiprofen-associated acute tubulointerstitial nephritis." Am J Nephrol 11 (1991): 144-6
Fong J, Gora ML "Reversible renal insufficiency following ketorolac therapy." Ann Pharmacother 27 (1993): 510-2
Goebel KM, Mueller-Brodmann W "Reversible overt nephropathy with Henoch-Schonlein purpura due to piroxicam." Br Med J (Clin Res Ed) 284 (1982): 311-2
Bergamo RR, Cominelli F, Kopple JD, Zipser RD "Comparative acute effects of aspirin, diflunisal, ibuprofen and indomethacin on renal function in healthy men." Am J Nephrol 9 (1989): 460-3
Vitting KE, Nichols NJ, Seligson GR "Naproxen and acute renal failure in a runner." Ann Intern Med 105 (1986): 144
Kharasch MS, Johnson KM, Strange GR "Cardiac arrest secondary to indomethacin-induced renal failure: a case report." J Emerg Med 8 (1990): 51-4
Munn E, Lynn KL, Bailey RR "Renal papillary necrosis following regular consumption of non-steroidal anti-inflammatory drugs." N Z Med J 95 (1982): 213-4
Brezin JH, Katz SM, Schwartz AB, Chinitz JL "Reversible renal failure and nephrotic syndrome associated with nonsteroidal anti-inflammatory drugs." N Engl J Med 301 (1979): 1271-4
Brater DC, Brown-Cartwright D, Anderson SA, Uaamnuichai M "Effect of high-dose etodolac on renal function." Clin Pharmacol Ther 42 (1987): 283-9
Blackshear JL, Davidman M, Stillman MT "Identification of risk for renal insufficiency from nonsteroidal anti-inflammatory drugs." Arch Intern Med 143 (1983): 1130-4
Handa SP "Drug-induced acute interstitial nephritis: report of 10 cases." Can Med Assoc J 135 (1986): 1278-81
Schwartzman M, D'Agati V "Spontaneous relapse of naproxen-related nephrotic syndrome." Am J Med 82 (1987): 329-32
Poitirt TI "Reversible renal failure associated with ibuprofen: case report and review of the literature." Drug Intell Clin Pharm 18 (1984): 27-32
Blackwell E, Loughlin K, Dumler F, Smythe M "Nabumetone-associated interstitial nephritis." Pharmacotherapy 15 (1995): 669-72
Pascoe MD, Gordon GD, Temple-Camp CR "Tolmetin-induced acute renal failure." S Afr Med J 70 (1986): 232-3
Sennesael J, Van den Houte K, Verbeelen D "Reversible membranous glomerulonephritis associated with ketoprofen." Clin Nephrol 26 (1986): 213-5
Boras-Uber LA, Brackett NC Jr "Ketorolac-induced acute renal failure." Am J Med 92 (1992): 450-2

Acunivive 90 Injection System

Generic Name: ketorolac

Brand name: Sprix, Toradol

Synonyms: Ketorolac (nasal), Ketorolac (Nasal)

What is Acunivive 90 Injection System?

Alimta

Generic Name: pemetrexed

Brand name: Alimta

Synonyms: n.a.

What is Alimta?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions