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Acunivive 90 Injection System and Eplerenone

Determining the interaction of Acunivive 90 Injection System and Eplerenone and the possibility of their joint administration.

Check result:

Acunivive 90 Injection System <> Eplerenone

Relevance: 11.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ketorolac together with eplerenone may decrease the effects of eplerenone. Contact your doctor if you experience signs of high blood pressure which may include headache, blurred vision, trouble concentrating, dizziness. And fatigue. If your doctor does prescribe these medications together, you may need a dose adjustment or need your blood pressure more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of eplerenone. The proposed mechanism is NSAID-induced inhibition of renal prostaglandin synthesis, which results in unopposed pressor activity producing hypertension. In addition, NSAIDs can cause fluid retention, which also affects blood pressure. Although the interaction has not specifically been studied with eplerenone, it has been reported with other potassium-sparing antihypertensive drugs such as ACE inhibitors. In patients with renal impairment receiving these antihypertensive agents, concomitant use of NSAIDs has also resulted in severe hyperkalemia.

MANAGEMENT: Patients receiving eplerenone who require prolonged (greater than 1 week) concomitant therapy with an NSAID should have blood pressure monitored more closely following initiation, discontinuation, or change of dosage of the NSAID. The interaction is not expected to occur with low doses (e.g., low-dose aspirin) or intermittent short-term administration of NSAIDs.

References

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Radack KL, Deck CC, Bloomfield SS "Ibuprofen interferes with the efficacy of antihypertensive drugs: a randomized, double-blind, placebo-controlled trial of ibuprofen compared with acetaminophen." Ann Intern Med 107 (1987): 628-35
Ahmad S "Indomethacin-enalapril interaction: an alert." South Med J 84 (1991): 411-2
Moore TJ, Crantz FR, Hollenberg NK "Contribution of prostaglandins to the antihypertensive action of captopril in essential hypertension." Hypertension 3 (1981): 168-73
Allon M, Pasque CB, Rodriguez M "Interaction of captopril and ibuprofen on glomerular and tubular function in humans." Am J Physiol 259 (1990): f233-8
Seto S, Aoi W, Iwami K, et al "Effect of propranolol and indomethacin on the depressor action of captopril in patients with essential hypertension." Clin Exp Hypertens 9 (1987): 623-7
"Product Information. Inspra (eplerenone)." Searle, Chicago, IL.
Morgan T, Anderson A "Interaction of indomethacin with felodipine and enalapril." J Hypertens 11 (1993): S338-9
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Townend JN, Doran J, Lote CJ, Davies MK "Peripheral haemodynamic effects of inhibition of prostaglandin synthesis in congestive heart failure and interactions with captopril." Br Heart J 73 (1995): 434-41
Polonia J, Boaventura I, Gama G, Camoes I, Bernardo F, Andrade P, Nunes JP, Brandao F, Cerqueiragomes M "Influence of non-steroidal anti-inflammatory drugs on renal function and 24h ambulatory blood pressure-reducing effects of enalapril and nifedipine gastrointestinal therapeutic system in hypertensive patients." J Hypertens 13 (1995): 925-31

Acunivive 90 Injection System

Generic Name: ketorolac

Brand name: Sprix, Toradol

Synonyms: Ketorolac (nasal), Ketorolac (Nasal)

What is Acunivive 90 Injection System?

Eplerenone

Generic Name: eplerenone

Brand name: Inspra

Synonyms: n.a.

What is Eplerenone?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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