Acunivive 90 Injection System and First-Vancomycin 25

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using vancomycin together with ketorolac. Both medications can be harmful to the kidneys, and these effects are increased when the medications are used together. Symptoms of kidney damage include swelling, weight gain, feeling short of breath, drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, pain in your lower back, and urinating more or less than usual or not at all. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special tests to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: When administered concomitantly, vancomycin and ketorolac may have additive nephrotoxic effects. Ketorolac, like other nonsteroidal anti-inflammatory drugs (NSAIDs), inhibits vasodilatory renal prostaglandin synthesis. Renal dysfunction associated with ketorolac has been reported to be dose-related and reversible following treatment discontinuation. In addition, chronic use of NSAIDs may also be associated with renal toxicities, including renal failure. The mechanism of vancomycin-induced nephrotoxicity is unknown; however, the risk may be increased in patients with preexisting risk factors for nephrotoxicity, high vancomycin blood levels, or prolonged treatment. Data for this interaction are limited to a case report of acute transient renal failure and gastrointestinal bleeding requiring transfusion following uncomplicated surgery and treatment with ketorolac and IV vancomycin in a previously healthy middle-aged man. Data are not available for other NSAIDs.

MANAGEMENT: Caution is recommended in patients receiving ketorolac or other NSAIDs in combination with IV vancomycin, particularly in patients with preexisting risk factors for nephrotoxicity. Renal function and vancomycin therapeutic drug monitoring is recommended according to local policies and protocols. The dose and duration of concomitant NSAID therapy should also be minimized where possible.

Acunivive 90 Injection System

Generic Name: ketorolac

Brand name: Sprix, Toradol

Synonyms: Ketorolac (nasal), Ketorolac (Nasal)

What is Acunivive 90 Injection System?

First-Vancomycin 25

Generic Name: vancomycin

Brand name: FIRST-Vancomycin, Vancocin HCl Pulvules, First-Vancomycin 25, First-Vancomycin 50, Firvanq, Vancocin, First-Vancomycin 25, First-Vancomycin 50

Synonyms: Vancomycin

What is First-Vancomycin 25?