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Acunivive 90 Injection System and Pitressin Synthetic

Determining the interaction of Acunivive 90 Injection System and Pitressin Synthetic and the possibility of their joint administration.

Check result:
Acunivive 90 Injection System <> Pitressin Synthetic
Relevance: 11.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ketorolac can sometimes enhance the effects of vasopressin. Although not common, this may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In serious cases, hyponatremia can lead to seizure, coma, or even death. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, and/or sudden weight gain, as these may be symptoms of water intoxication and hyponatremia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The antidiuretic response to vasopressin or desmopressin may be potentiated by certain drugs, including nonsteroidal anti-inflammatory agents, selective serotonin reuptake inhibitors, tricyclic/tetracyclic antidepressants, carbamazepine, chlorpropamide, chlorpromazine, clofibrate, eslicarbazepine, fludrocortisone, haloperidol, lamotrigine, oxcarbazepine, urea, and some antineoplastic agents (e.g., vinca alkaloids, cisplatin, cyclophosphamide). These drugs can occasionally cause fluid retention, in some cases secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Coadministration with vasopressin or desmopressin may, therefore, increase the risk of water intoxication and/or hyponatremia. Seizure and coma in association with severe hyponatremia have been reported during concomitant use of desmopressin and imipramine or ibuprofen. The elderly may be particularly susceptible.

MANAGEMENT: Caution is recommended if vasopressin or desmopressin is used in combination with drugs that can cause fluid retention or SIADH. Serum electrolytes, especially sodium, as well as BUN and creatinine should be monitored regularly. Patients should be advised to seek medical attention if they develop signs and symptoms of water intoxication or hyponatremia such as anorexia, nausea, vomiting, headache, malaise, lethargy, irritability, difficulty concentrating, memory impairment, confusion, weakness, muscle spasm, unsteadiness (which may lead to falls), anuria, and weight gain. Early treatment may help prevent progression to seizure, coma, respiratory arrest, and death.

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Acunivive 90 Injection System

Generic Name: ketorolac

Brand name: Sprix, Toradol

Synonyms: Ketorolac (nasal), Ketorolac (Nasal)

What is Acunivive 90 Injection System?
Pitressin Synthetic

Generic Name: vasopressin

Brand name: Pitressin Synthetic, Vasostrict, Pitressin

Synonyms: Pitressin Injection

What is Pitressin Synthetic?
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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions
Doktika World
Interaction with food and lifestyle
  1. Acunivive 90 Injection System
  2. Pitressin Synthetic
Disease interaction
  1. Acunivive 90 Injection System
  2. Pitressin Synthetic