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Acunivive 90 Injection System and Tyzeka

Determining the interaction of Acunivive 90 Injection System and Tyzeka and the possibility of their joint administration.

Check result:
Acunivive 90 Injection System <> Tyzeka
Relevance: 11.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ketorolac can affect kidney function and may increase the blood levels and effects of telbivudine when used together. You may be more likely to develop serious side effects of telbivudine including liver, muscle, and nerve problems. Contact your doctor if you develop skin rash or itching; loss of appetite; abdominal pain; nausea; vomiting; dark colored urine; yellowing of the skin or eyes; unexplained muscle aches, pain, tenderness, or weakness; difficulty walking; or numbness, burning or tingling in your hands and feet. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek immediate medical attention if you experience extreme tiredness or weakness, dizziness, lightheadedness, muscle pain, difficulty breathing, stomach pain, nausea, vomiting, and/or a fast or irregular heart beat, as these may be signs and symptoms of a serious medical condition known as lactic acidosis that can sometimes occur during treatment with medications like telbivudine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Because telbivudine is primarily eliminated by renal excretion, coadministration with drugs that affect renal function may alter the plasma concentrations of telbivudine and/or the coadministered drug.

MANAGEMENT: Caution is advised if telbivudine is prescribed in combination with potentially nephrotoxic drugs (e.g., aminoglycosides; polypeptide, glycopeptide, and polymyxin antibiotics; amphotericin B; adefovir; cidofovir; tenofovir; foscarnet; cisplatin; deferasirox; gallium nitrate; lithium; mesalamine; certain immunosuppressants; intravenous bisphosphonates; intravenous pentamidine; high intravenous dosages of methotrexate; high dosages and/or chronic use of nonsteroidal anti-inflammatory agents). Renal function should be evaluated prior to and during therapy with telbivudine. Adjustment of dosing interval is required in patients with renal insufficiency (creatinine clearance below 50 mL/min) at baseline or during treatment in accordance with the manufacturer's product labeling.

References
  • "Product Information. Tyzeka (telbivudine)." IDEC Pharmaceuticals Corporation, San Diego, CA.
Acunivive 90 Injection System

Generic Name: ketorolac

Brand name: Sprix, Toradol

Synonyms: Ketorolac (nasal), Ketorolac (Nasal)

Tyzeka

Generic Name: telbivudine

Brand name: Tyzeka

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle