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Acyclovir Buccal Tablets and Meperidine and Promethazine Capsules

Determining the interaction of Acyclovir Buccal Tablets and Meperidine and Promethazine Capsules and the possibility of their joint administration.

Check result:

Acyclovir Buccal Tablets <> Meperidine and Promethazine Capsules

Relevance: 04.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using meperidine together with acyclovir may increase the effects of meperidine. Contact your doctor if you experience extreme drowsiness, muscle weakness, confusion, cold and clammy skin, pinpoint pupils, shallow breathing, slow heart rate, fainting, or coma. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Acyclovir may increase the plasma concentrations of meperidine and normeperidine, the metabolite that has been associated with adverse effects such as lethargy, agitation, and seizures. The mechanism of interaction is unknown. Increased pharmacologic and adverse effects of meperidine may occur.

MANAGEMENT: Caution is recommended if meperidine is used with acyclovir or its prodrug, valacyclovir. Patients should be monitored for tremor, seizures, CNS and respiratory depression, and cardiac arrhythmias.

References

Johnson R, Douglas J, Corey L, Krasney H "Adverse effects with acyclovir and meperidine." Ann Intern Med 103 (1985): 962-3
"Product Information. Demerol (meperidine)." Sanofi Winthrop Pharmaceuticals, New York, NY.

Acyclovir Buccal Tablets

Generic Name: acyclovir

Brand name: Sitavig, Zovirax

Synonyms: Acyclovir, Acyclovir (Systemic)

What is Acyclovir Buccal Tablets?

Meperidine and Promethazine Capsules

Generic Name: meperidine / promethazine

Brand name:

Synonyms: Meperidine and Promethazine

What is Meperidine and Promethazine Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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