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Acyclovir Buccal Tablets and Retrovir Intravenous

Determining the interaction of Acyclovir Buccal Tablets and Retrovir Intravenous and the possibility of their joint administration.

Check result:

Acyclovir Buccal Tablets <> Retrovir Intravenous

Relevance: 04.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Excessive lethargy has been reported in some patients with coadministration of acyclovir and zidovudine. Concomitant use of these drugs in large trials has not confirmed this interaction.

References

Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
Tartaglione TA, Collier AC, Opheim K, Gianola FG, Benedetti J, Corey L "Pharmacokinetic evaluations of low- and high-dose zidovudine plus high-dose acyclovir in patients with symptomatic human immunodeficiency virus infection." Antimicrob Agents Chemother 35 (1991): 2225-31
Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60
Cerner Multum, Inc. "Australian Product Information." O 0
Cooper DA, Pedersen C, Auiti F, et al "The efficacy and safety of zidovudine with or without acyclovir in the treatment of patients with AIDS-related complex." AIDS 5 (1991): 933-43
Bach MC "Possible drug interaction during therapy with azidothymidine and acyclovir for AIDS." N Engl J Med 316 (1987): 547
Cerner Multum, Inc "ANVISA Bulário Eletrônico. Available from: URL: http://www.anvisa.gov.br/datavisa/fila_bula/index.asp." O 0 (2015):

Acyclovir Buccal Tablets

Generic Name: acyclovir

Brand name: Sitavig, Zovirax

Synonyms: Acyclovir, Acyclovir (Systemic)

What is Acyclovir Buccal Tablets?

Retrovir Intravenous

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Retrovir (oral/injection), Retrovir

What is Retrovir Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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