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Acyclovir Buccal Tablets and Varicella Virus Vaccine

Determining the interaction of Acyclovir Buccal Tablets and Varicella Virus Vaccine and the possibility of their joint administration.

Check result:

Acyclovir Buccal Tablets <> Varicella Virus Vaccine

Relevance: 04.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

If you are currently being treated with acyclovir, you should talk to your doctor before receiving varicella virus vaccine. Antiviral medications like acyclovir can reduce the activity of the vaccine. To ensure adequate vaccine response, you should not receive varicella virus vaccine until at least 24 hours after you complete your acyclovir therapy. If you have just been vaccinated, it would be best to wait at least 14 days before using acyclovir. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concomitant use of live, attenuated varicella virus vaccine or zoster vaccine with acyclovir, famciclovir, or valacyclovir may result in diminished immunologic response to the vaccine. Although clinical data are lacking, theoretical concern exists that antiviral activity against the vaccine strain may prevent a sufficient degree of replication to occur in order to induce a protective immune response. Acyclovir, specifically, has demonstrated activity against the Oka strain of live, attenuated varicella-zoster virus used in the vaccines.

MANAGEMENT: Acyclovir, famciclovir, and valacyclovir should not be used for at least 24 hours before administration of live, attenuated varicella virus vaccine or zoster vaccine. In addition, these antiviral agents should generally be avoided for 14 days after vaccination.

References

"Product Information. Zovirax (acyclovir)." Mylan Pharmaceuticals Inc, Morgantown, WV.
US Centers for Disease Control and Prevention (CDC) "Recommended immunization schedule for adults aged 19 years or older, United States, 2017 Available from: URL: https://www.cdc.gov/vaccines/schedules/downloads/adult/adult-combined-schedule-bw.pdf." ([2017, Feb]):

Acyclovir Buccal Tablets

Generic Name: acyclovir

Brand name: Sitavig, Zovirax

Synonyms: Acyclovir, Acyclovir (Systemic)

What is Acyclovir Buccal Tablets?

Varicella Virus Vaccine

Generic Name: varicella virus vaccine

Brand name: Varivax

Synonyms: Varicella virus (chickenpox) vaccine

What is Varicella Virus Vaccine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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