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Aczone and Methotrexate Sodium

Determining the interaction of Aczone and Methotrexate Sodium and the possibility of their joint administration.

Check result:

Aczone <> Methotrexate Sodium

Relevance: 06.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Folate antagonists have been reported to possibly increase the likelihood of hematologic reactions (e.g., agranulocytosis, anemia) associated with oral dapsone. The effect on topically administered dapsone is unknown. Exposure to dapsone from the recommended topical dose for acne vulgaris is about 1% of that from a 100 mg oral dose.

References

"Product Information. Aczone (dapsone topical)." QLT USA, Inc, Fort Collins, CO.

Aczone

Generic Name: dapsone topical

Brand name: Aczone

Synonyms: n.a.

What is Aczone?

Methotrexate Sodium

Generic Name: methotrexate

Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free

Synonyms: Methotrexate

What is Methotrexate Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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