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Aczone Topical and Septra DS

Determining the interaction of Aczone Topical and Septra DS and the possibility of their joint administration.

Check result:

Aczone Topical <> Septra DS

Relevance: 09.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Systemic levels of dapsone and its metabolites following topical administration may be increased in the presence of trimethoprim/sulfamethoxazole (TMP/SMX). In a drug interaction study, systemic exposure (AUC) of dapsone and N-acetyl-dapsone were increased by about 40% and 20%, respectively, during coadministration with double-strength (160 mg/800 mg) TMP/SMX. Systemic exposure of dapsone hydroxylamine, a metabolite associated with hemolysis, was more than doubled by TMP/SMX. The clinical significance of these changes is unknown. Exposure from the recommended topical dose for acne vulgaris is about 1% of that from a 100 mg oral dose, even when coadministered with TMP/SMX. There were no effects on the systemic levels of TMP or SMX.

References

"Product Information. Aczone (dapsone topical)." QLT USA, Inc, Fort Collins, CO.

Aczone Topical

Generic Name: dapsone topical

Brand name: Aczone

Synonyms: Aczone

What is Aczone Topical?

Septra DS

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Septra, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS

Synonyms: Septra DS (Oral)

What is Septra DS?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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