Aczone Topical and Tracleer (Bosentan Tablets for Oral Suspension)
Determining the interaction of Aczone Topical and Tracleer (Bosentan Tablets for Oral Suspension) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Theoretically, coadministration of dapsone with inducers of CYP450 3A4 such as rifamycins, anticonvulsants, barbiturates, and St. John's wort may increase the formation of dapsone hydroxylamine, a metabolite associated with hemolysis. Dose-related hemolysis is the most common adverse event associated with oral dapsone in both patients with or without glucose-6-phosphate dehydrogenase (G6PD) deficiency. While clinical studies have not demonstrated evidence of clinically significant anemia in patients treated with dapsone 5% gel for acne vulgaris, an increased reticulocyte count and a decreased hemoglobin level were noted to be associated in a G6PD-deficient patient. Exposure to dapsone from the recommended topical dose is about 1% of that from a 100 mg oral dose.
- "Product Information. Aczone (dapsone topical)." QLT USA, Inc, Fort Collins, CO.
Generic Name: dapsone topical
Brand name: Aczone
Synonyms: Aczone
Generic Name: bosentan
Brand name: Tracleer
Synonyms: Tracleer
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aczone Topical-Tracleer (Bosentan Tablets)
- Aczone Topical-Tradjenta
- Aczone Topical-Tramacet
- Aczone Topical-Tramadol
- Aczone Topical-Tramadol and acetaminophen
- Aczone Topical-Tramadol Capsules
- Tracleer (Bosentan Tablets for Oral Suspension)-Adacel
- Tracleer (Bosentan Tablets for Oral Suspension)-Adacel Intramuscular
- Tracleer (Bosentan Tablets for Oral Suspension)-Adacel TDAP
- Tracleer (Bosentan Tablets for Oral Suspension)-Adagen
- Tracleer (Bosentan Tablets for Oral Suspension)-Adalat CC
- Tracleer (Bosentan Tablets for Oral Suspension)-Adalimumab