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Adacel and Siponimod

Determining the interaction of Adacel and Siponimod and the possibility of their joint administration.

Check result:

Adacel <> Siponimod

Relevance: 17.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.ADJUST DOSING INTERVAL: The administration of inactivated, killed, or otherwise noninfectious vaccines during siponimod therapy is generally safe but may be associated with a diminished or suboptimal immunologic response. Vaccination may be less effective during and for up to one month after discontinuation of siponimod therapy. MANAGEMENT: Immune response to vaccines may be reduced during and for up to one month after discontinuation of siponimod therapy. Treatment with siponimod should be paused 1 week prior to and for 4 weeks after vaccination. References "Product Information. Mayzent (siponimod)." Novartis Pharmaceuticals, East Hanover, NJ.

Professional:

ADJUST DOSING INTERVAL: The administration of inactivated, killed, or otherwise noninfectious vaccines during siponimod therapy is generally safe but may be associated with a diminished or suboptimal immunologic response. Vaccination may be less effective during and for up to one month after discontinuation of siponimod therapy.

MANAGEMENT: Immune response to vaccines may be reduced during and for up to one month after discontinuation of siponimod therapy. Treatment with siponimod should be paused 1 week prior to and for 4 weeks after vaccination.

References

"Product Information. Mayzent (siponimod)." Novartis Pharmaceuticals, East Hanover, NJ.

Adacel

Generic Name: diphtheria toxoid / pertussis, acellular / tetanus toxoid

Brand name: Adacel, Boostrix

Synonyms: n.a.

What is Adacel?

Siponimod

Generic Name: siponimod

Brand name: Mayzent, Mayzent Starter Pack

Synonyms: n.a.

What is Siponimod?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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