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Adalat CC and EC-Naprosyn

Determining the interaction of Adalat CC and EC-Naprosyn and the possibility of their joint administration.

Check result:

Adalat CC <> EC-Naprosyn

Relevance: 06.04.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before using naproxen, tell your doctor if you also use NIFEdipine. The combination may cause your blood pressure to increase. You may need a dose adjustment or your blood pressure checked more often. Also, if you are already taking the combination and stop taking naproxen, your blood pressure may decrease. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data indicate that some cyclooxygenase inhibitors may attenuate the antihypertensive effects of some calcium channel blockers. The mechanism appears to be related to an alteration of vascular tone, which is dependent on prostacyclins and other vasodilatory prostanoids. When a nonsteroidal anti-inflammatory drug (NSAID) is added to the regimen of a patient who is already taking a calcium channel blocker, increased blood pressure may result. Also, the clinician should be aware that the risk of hypotension is increased when NSAIDs are withdrawn from the regimen.

MANAGEMENT: Monitoring for altered blood pressure control is recommended.

References

Cremer KF, Pieper JA, Joyal M, Mehta J "Effects of diltiazem, dipyridamole, and their combination on hemostasis." Clin Pharmacol Ther 36 (1984): 641-4
"Product Information. Arthrotec (diclofenac-misoprostol)." Searle, Skokie, IL.
Deleeuw PW "Nonsteroidal anti-inflammatory drugs and hypertension: the risks in perspective." Drugs 51 (1996): 179-87
"Product Information. Duract (bromfenac)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Zanchetti A, Hansson L, Leonetti G, et al. "Low-dose aspirin does not interfere with the blood pressure-lowering effects of antihypertensive therapy." J Hypertens 20 (2002): 1015-1022
Houston MC, Weir M, Gray J, et al "The effects of nonsteroidal anti-inflammatory drugs on blood pressures of patients with hypertension controlled by verapamil." Arch Intern Med 155 (1995): 1049-54
Altman R, Scazziota A, Dujovne C "Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation." Clin Pharmacol Ther 44 (1988): 320-5
Minuz P, Pancera P, Ribul M, et al "Amlodipine and haemodynamic effects of cyclo-oxygenase inhibition." Br J Clin Pharmacol 39 (1995): 45-50
Ring ME, Corrigan JJ, Fenster PE "Effects of oral diltiazem on platelet function: alone and in combination with "low dose" aspirin." Thromb Res 44 (1986): 391-400

Adalat CC

Generic Name: nifedipine

Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat

Synonyms: n.a.

What is Adalat CC?

EC-Naprosyn

Generic Name: naproxen

Brand name: EC-Naprosyn, Aleve, Flanax Pain Reliever, Midol Extended Relief, Naprelan 375, Naprosyn, Anaprox-DS, Naprelan 500, Flanax, Naprelan, Anaprox, Naproxen Sodium, Aleve Caplet, Aleve Gelcap, Aleve Easy Open Arthritis

Synonyms: n.a.

What is EC-Naprosyn?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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