Adalat CC and Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate
Determining the interaction of Adalat CC and Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Efavirenz may reduce the blood levels and effects of NIFEdipine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with efavirenz may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is accelerated clearance due to induction of CYP450 3A4 activity by efavirenz.
MANAGEMENT: Caution is advised if efavirenz must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever efavirenz is added to or withdrawn from therapy.
- "Product Information. Sustiva (efavirenz)." DuPont Pharmaceuticals, Wilmington, DE.
Generic Name: nifedipine
Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat
Synonyms: n.a.
Generic Name: efavirenz / emtricitabine / tenofovir
Brand name: Atripla
Synonyms: Efavirenz, emtricitabine, and tenofovir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Adalat CC-Efavirenz, lamivudine, and tenofovir
- Adalat CC-Efavirenz, Lamivudine, and Tenofovir Disoproxil Fumarate
- Adalat CC-Effaclor Duo
- Adalat CC-Effer-K
- Adalat CC-Effer-K Tablets
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- Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate-Adalimumab
- Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate-Adalimumab Prefilled Pens and Syringes
- Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate-Adalimumab Subcutaneous
- Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate-Adalimumab Vials
- Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate-Adalimumab-adbm Subcutaneous
- Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate-Adalimumab-atto Subcutaneous