Adasuve and Phenytek
Determining the interaction of Adasuve and Phenytek and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One case report has suggested that loxapine may decrease serum phenytoin levels. The mechanism may be related to an increase in phenytoin metabolism. The clinical significance is unknown. If loxapine and phenytoin must be used together, close observation for clinical evidence of altered phenytoin effect is recommended. Patients should be advised to notify their physician if they experience loss of seizure control.
- Ryan GM, Matthews PA "Phenytoin metabolism stimulated by loxapine." Drug Intell Clin Pharm 11 (1977): 428-9
Generic Name: loxapine
Brand name: Adasuve, Loxitane
Synonyms: Adasuve Inhalation
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.