Adderall XR and Midodrine Hydrochloride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using midodrine together with amphetamine can increase the risk of hypertension. Midodrine may cause significant increases in blood pressure by constricting the blood vessels, and the risk for complications may be increased when used with other drugs that also affect blood pressure such as decongestants, stimulants, and certain medications for headache, glaucoma, or eye redness relief. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor immediately if you experience symptoms that could indicate an acute increase in blood pressure, such as severe or throbbing headache, pounding in the ears, chest pain, and blurred vision. In some cases, sleeping with the head of the bed elevated or taking the last daily dose of midodrine 3 to 4 hours before bedtime may help lessen the effects on blood pressure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The pressor effects of midodrine may be potentiated by the concomitant use of other agents that cause vasoconstriction, including sympathomimetics and ergot alkaloids. Midodrine is an alpha-adrenergic agonist and may cause marked elevation of supine arterial blood pressure, or supine hypertension. In clinical trials, systolic pressures of about 200 mmHg were observed overall in about 13.4% of patients given 10 mg of midodrine, the majority of whom also had relatively elevated pretreatment systolic blood pressures (mean 170 mmHg). There is no experience in patients with initial supine systolic pressure above 180 mmHg, as those patients were excluded from clinical trials. Sitting blood pressures were also elevated by midodrine therapy.

MANAGEMENT: Caution is advised if midodrine must be used in combination with other agents that can increase blood pressure. Supine and sitting blood pressures should be closely monitored. Supine hypertension can often be controlled by keeping the patient from being fully supine, for example, sleeping with the head of the bed elevated. Taking the last daily dose of midodrine 3 to 4 hours before bedtime may also help to minimize nighttime supine hypertension. Patients should be advised to contact their physician immediately if they experience symptoms of supine hypertension such as cardiac awareness, pounding in the ears, headache, and blurred vision. Midodrine should be discontinued if supine hypertension persists.

Adderall XR

Generic Name: amphetamine / dextroamphetamine

Brand name: Adderall, Adderall XR, Mydayis

Synonyms: n.a.

What is Adderall XR?

Midodrine Hydrochloride

Generic Name: midodrine

Brand name: Proamatine, Orvaten

Synonyms: Midodrine

What is Midodrine Hydrochloride?