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Adderall XR and Nuvigil

Determining the interaction of Adderall XR and Nuvigil and the possibility of their joint administration.

Check result:
Adderall XR <> Nuvigil
Relevance: 05.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In single-dose pharmacokinetic studies, healthy volunteers given modafinil (200 mg) with dextroamphetamine (10 mg) or methylphenidate (40 mg) exhibited a delay in the absorption of modafinil by approximately 1 hour. The mechanism of interaction is unknown. No other alterations in the pharmacokinetics of any of the drugs were observed. Although not studied, the interaction is likely to also occur with the various prodrug, racemic, and enantiomeric formulations of these drugs (e.g., amphetamine, lisdexamfetamine, dexmethylphenidate, armodafinil).

References
  • "Product Information. Nuvigil (armodafinil)." Cephalon Inc, West Chester, PA.
  • Cerner Multum, Inc. "Australian Product Information." O 0
  • "Product Information. Provigil (modafinil)." Cephalon, Inc, West Chester, PA.
Adderall XR

Generic Name: amphetamine / dextroamphetamine

Brand name: Adderall, Adderall XR, Mydayis

Synonyms: n.a.

Nuvigil

Generic Name: armodafinil

Brand name: Nuvigil

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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