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Adderall XR and Tham

Determining the interaction of Adderall XR and Tham and the possibility of their joint administration.

Check result:

Adderall XR <> Tham

Relevance: 05.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using amphetamine together with tromethamine, this can increase the effects of amphetamine. Call the doctor if you experience restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safey use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Alkalinization of the urine can decrease the renal elimination of amphetamines. Amphetamine effects may be prolonged, and the risk of toxicity may be increased.

MANAGEMENT: Urinary alkalinizers should generally not be used with amphetamines, particularly in an amphetamine overdose situation.

References

Anggard E, Jonsson LE, Hogmark AL, Gunne LM "Amphetamine metabolism in amphetamine psychosis." Clin Pharmacol Ther 14 (1973): 870-80
Wilkinson GR, Beckett AH "Absorption, metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47
Davis JM, Kopin IJ, Lemberger L, Axelrod J "Effects of urinary pH on amphetamine metabolism." Ann N Y Acad Sci 179 (1971): 493-501
Beckett AH, Rowland M "Urinary excretion kinetics of amphetamine in man." J Pharm Pharmacol 17 (1965): 628-39
Beckett AH, Salmon JA, Mitchard M "The relation between blood levels and urinary excretion of amphetamine under controlled acidic and under fluctuating urinary pH values using [C]amphetamine." J Pharm Pharmacol 21 (1969): 251-8
Beckett AH, Rowland M, Turner P "Influence of urinary pH on excretion of amphetamine." Lancet 1 (1965): 303

Adderall XR

Generic Name: amphetamine / dextroamphetamine

Brand name: Adderall, Adderall XR, Mydayis

Synonyms: n.a.

What is Adderall XR?

Tham

Generic Name: tromethamine

Brand name: Tham

Synonyms: n.a.

What is Tham?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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