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Adderall XR and Thionex Topical

Determining the interaction of Adderall XR and Thionex Topical and the possibility of their joint administration.

Check result:
Adderall XR <> Thionex Topical
Relevance: 05.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Some of the medication in lindane topical can be absorbed through the skin into the bloodstream and produce seizures on rare occasions. The risk may be increased when used with other medications that can also cause seizures such as amphetamine. This may be more likely to occur in very young children or the elderly; people undergoing alcohol or drug withdrawal; and those who have a history of seizures or a condition affecting the central nervous system such as a brain tumor or head trauma. Excessive or inappropriate use or accidental ingestion of lindane topical can also lead to seizures. Talk to a healthcare professional if you have any questions or concerns. You should follow closely the instructions for use of lindane topical given by the prescriber, and keep the product out of reach of children. Do not exceed the frequency and duration of use recommended on the product label or prescribed by the doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Lindane penetrates human skin and has the potential to cause central nervous system toxicity. Seizures have been reported after excessive use or oral ingestion of lindane. There may be a theoretical risk of increased seizure potential when lindane is used with selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics), monoamine oxidase inhibitors, neuroleptic agents, central nervous system stimulants, opioids, tricyclic antidepressants, other tricyclic compounds (e.g., cyclobenzaprine, phenothiazines), and/or any substance that can reduce the seizure threshold (e.g., carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, theophylline). These agents are often individually epileptogenic and may have additive effects when combined.

MANAGEMENT: Caution is advised if lindane is used with any substance that can reduce the seizure threshold, particularly in the very young or the elderly and in patients with epilepsy, a history of seizures, or other risk factors for seizures (e.g., head trauma, brain tumor, metabolic disorders, alcohol and drug withdrawal, CNS infections). Lindane should be used according to recommended dosage and directions for application.

References
  • "Product Information. Kwell (lindane)." Reed and Carnrick, Jersey City, NJ.
  • Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9
  • Solomon BA, Haut SR, Carr EM, Shalita AR "Neurotoxic reaction to lindane in an HIV-seropositive patient: an old medication's new problem." J Fam Pract 40 (1995): 291-6
  • Munk ZM, Nantel A "Acute lindane poisoning with development of muscle necrosis." Can Med Assoc J 117 (1977): 1050-4
  • Telch J, Jarvis DA "Acute intoxication with lindane (gamma benzene hexachloride)." Can Med Assoc J 126 (1982): 662-3
  • Ramchander V, Cameron ES, Reid HF "Lindane toxicity in an infant." West Indian Med J 40 (1991): 41-3
  • Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2
  • Tenenbein M "Seizures after lindane therapy." J Am Geriatr Soc 39 (1991): 394-5
  • Pramanik AK, Hansen RC "Transcutaneous gamma benzene hexachloride absorption and toxicity in infants and children." Arch Dermatol 115 (1979): 1224-5
Adderall XR

Generic Name: amphetamine / dextroamphetamine

Brand name: Adderall, Adderall XR, Mydayis

Synonyms: n.a.

Thionex Topical

Generic Name: lindane topical

Brand name:

Synonyms: Lindane topical, Lindane

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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