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Adderall XR and Urex

Determining the interaction of Adderall XR and Urex and the possibility of their joint administration.

Check result:

Adderall XR <> Urex

Relevance: 05.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Methenamine may reduce the blood levels of amphetamine, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Urinary acidifying agents such as ammonium chloride, sodium acid phosphate, and methenamine salts may lower the blood levels and efficacy of amphetamines. Acidifying the urine has been reported to increase the concentration of the ionized species of the amphetamine molecule, thereby inhibiting renal tubular absorption and increasing its urinary excretion. In one study, approximately 55% of an amphetamine dose was excreted unchanged when the urine was acidic, versus less than 3% when the urine was alkaline. Amphetamine half-life has also been reported to shorten by one-half or more when urine is acidic rather than alkaline. Acidification of the urine has been employed successfully in the treatment of amphetamine overdose.

MANAGEMENT: Patients receiving an amphetamine in combination with urinary acidifying agents should be monitored for potentially diminished pharmacologic response to the amphetamine.

References

Beckett AH, Rowland M, Turner P "Influence of urinary pH on excretion of amphetamine." Lancet 1 (1965): 303
"Product Information. Dexedrine (dextroamphetamine)" SmithKline Beecham, Philadelphia, PA.
Gary NE, Saidi P "Methamphetamine intoxication. A speedy new treatment." Am J Med 64 (1978): 537-40
Wilkinson GR, Beckett AH "Absorption, metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47
Anggard E, Jonsson LE, Hogmark AL, Gunne LM "Amphetamine metabolism in amphetamine psychosis." Clin Pharmacol Ther 14 (1973): 870-80
Beckett AH, Salmon JA, Mitchard M "The relation between blood levels and urinary excretion of amphetamine under controlled acidic and under fluctuating urinary pH values using [C]amphetamine." J Pharm Pharmacol 21 (1969): 251-8
Beckett AH, Rowland M "Urinary excretion kinetics of amphetamine in man." J Pharm Pharmacol 17 (1965): 628-39
Davis JM, Kopin IJ, Lemberger L, Axelrod J "Effects of urinary pH on amphetamine metabolism." Ann N Y Acad Sci 179 (1971): 493-501
Beckett AH, Rowland M "Urinary excretion kinetics of methylamphetamine in man." J Pharm Pharmacol 17 (1965): s109-14

Adderall XR

Generic Name: amphetamine / dextroamphetamine

Brand name: Adderall, Adderall XR, Mydayis

Synonyms: n.a.

What is Adderall XR?

Urex

Generic Name: methenamine

Brand name: Hiprex, Mandelamine, Urex

Synonyms: Urex (Oral)

What is Urex?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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