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Adderall XR and Xadago

Determining the interaction of Adderall XR and Xadago and the possibility of their joint administration.

Check result:

Adderall XR <> Xadago

Relevance: 05.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using safinamide together with amphetamine may increase cardiovascular side effects such as blood pressure elevations and increased heart rate. While these effects are not expected to be dangerous in most people, there is a possibility for high blood pressure to occur which may require medical attention. Talk to your doctor if you have any questions or concerns, especially if you have a history of high blood pressure, irregular heart rhythm, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration of nonselective monoamine oxidase (MAO) inhibitors and sympathomimetic amines has been associated with severe hypertensive reactions. The mechanism involves a synergistic sympathomimetic effect due to enhanced norepinephrine storage in adrenergic neurons (MAOI activity) and increased liberation or decreased reuptake of catecholamines (sympathomimetic activity). Because safinamide is a selective MAO-B inhibitor, hypertensive reactions would not ordinarily be expected when used with sympathomimetic amines. However, one case of hypertensive crisis has been reported in a patient taking ephedrine with the recommended dosage of another selective MAO-B inhibitor.

MANAGEMENT: Coadministration of safinamide and sympathomimetic amines, such as methylphenidate, amphetamine, and their derivatives, is considered contraindicated.

References

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Adderall XR

Generic Name: amphetamine / dextroamphetamine

Brand name: Adderall, Adderall XR, Mydayis

Synonyms: n.a.

What is Adderall XR?

Xadago

Generic Name: safinamide

Brand name: Xadago

Synonyms: n.a.

What is Xadago?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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