Addyi and Junel Fe 1.5/30

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ethinyl estradiol may increase the blood levels of flibanserin. In some cases, this may increase the risk of side effects such as drowsiness and decreases in blood pressure that can lead to dizziness, lightheadedness, fainting, and accidental injury. You should take flibanserin at bedtime to minimize the risk of these effects. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Concomitant use of hormonal contraceptives has been associated with increased adverse effects of flibanserin. The mechanism of interaction has not been established, but may partially involve inhibition of flibanserin metabolism. Flibanserin is primarily metabolized by CYP450 3A4 and, to a lesser extent, by CYP450 2C19. Some oral contraceptives are considered weak inhibitors of these isoenzymes. In a meta-analysis of 17 oral contraceptive users and 91 non-users in Phase 1 studies, flibanserin peak plasma concentration (Cmax) and systemic exposure (AUC) were 30% and 40% higher, respectively, in oral contraceptive users than in non-users. In four clinical trials of flibanserin for the treatment of hypoactive sexual desire disorder, 1466 patients (43%) reported concomitant use of hormonal contraceptives at study enrollment. Although these trials were not prospectively designed to assess an interaction between flibanserin and hormonal contraceptives, patients treated with flibanserin who reported hormonal contraceptive use had a greater incidence of dizziness (13.4% vs 9.9%), somnolence (12.3% vs 10.6%), and fatigue (11.4% vs 7.5%) compared to treated patients who did not report hormonal contraceptive use. By contrast, there were no meaningful differences in the incidence of these adverse reactions in placebo-treated patients who reported or did not report hormonal contraceptive use.

MANAGEMENT: Caution is advised when flibanserin is used with hormonal contraceptives. Patients should be monitored for signs and symptoms of hypotension, syncope, and central nervous system depression.

Addyi

Generic Name: flibanserin

Brand name: Addyi

Synonyms: n.a.

What is Addyi?

Junel Fe 1.5/30

Generic Name: ethinyl estradiol / norethindrone

Brand name: Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Estrostep Fe, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Taytulla, Tilia Fe, Tri-Legest Fe, Blisovi 24 Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Tri-Norinyl, Zenchent, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: n.a.

What is Junel Fe 1.5/30?