Addyi and Lanoxin Pediatric

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Flibanserin may significantly increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Coadministration with flibanserin may significantly increase the serum concentrations of digoxin. The proposed mechanism is flibanserin inhibition of the P-glycoprotein-mediated renal tubular secretion of digoxin. In 24 healthy male and female study subjects, administration of a single 0.5 mg dose of digoxin following pretreatment with flibanserin 100 mg once daily for 5 days increased digoxin peak concentration (Cmax) and systemic exposure (AUC) by 1.5- and 2.0-fold, respectively, compared to administration of digoxin alone.

MANAGEMENT: Serum digoxin levels and pharmacologic effects should be closely monitored following the addition or withdrawal of flibanserin, and the digoxin dosage adjusted as needed. Patients should be advised to seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

Addyi

Generic Name: flibanserin

Brand name: Addyi

Synonyms: n.a.

What is Addyi?

Lanoxin Pediatric

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

What is Lanoxin Pediatric?