Addyi and Larotrectinib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with flibanserin may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) efflux transporter. In 24 healthy male and female study subjects, administration of a single 0.5 mg dose of digoxin, a P-gp probe substrate, following pretreatment with flibanserin 100 mg once daily for 5 days increased digoxin peak concentration (Cmax) and systemic exposure (AUC) by 1.5- and 2.0-fold, respectively, compared to administration of digoxin alone. MANAGEMENT: Caution is advised when flibanserin is prescribed with drugs that are P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever flibanserin is added to or withdrawn from therapy. References "Product Information. Addyi (flibanserin)." Sprout Pharmaceuticals, Raleigh, NC.

MONITOR: Coadministration with flibanserin may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) efflux transporter. In 24 healthy male and female study subjects, administration of a single 0.5 mg dose of digoxin, a P-gp probe substrate, following pretreatment with flibanserin 100 mg once daily for 5 days increased digoxin peak concentration (Cmax) and systemic exposure (AUC) by 1.5- and 2.0-fold, respectively, compared to administration of digoxin alone.

MANAGEMENT: Caution is advised when flibanserin is prescribed with drugs that are P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever flibanserin is added to or withdrawn from therapy.

Addyi

Generic Name: flibanserin

Brand name: Addyi

Synonyms: n.a.

What is Addyi?

Larotrectinib

Generic Name: larotrectinib

Brand name: Vitrakvi

Synonyms: n.a.

What is Larotrectinib?