Addyi and Prozac Weekly

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

FLUoxetine may increase the blood levels of flibanserin. In some cases, this may increase the risk of side effects such as drowsiness and decreases in blood pressure that can lead to dizziness, lightheadedness, fainting, and accidental injury. You should take flibanserin at bedtime to minimize the risk of these effects. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors of CYP450 2C19 may increase the plasma concentrations of flibanserin, which is partially metabolized by the isoenzyme. High plasma levels of flibanserin may increase the risk of severe hypotension, syncope, and central nervous system depression. In a pharmacogenomic study where female subjects were given flibanserin 100 mg once daily, flibanserin peak plasma concentration (Cmax) and systemic exposure (AUC) were increased 1.5- and 1.3-fold, respectively, in the nine subjects who were poor metabolizers of CYP450 2C19 compared to the eight subjects who were extensive metabolizers. Flibanserin half-life was 13.5 hours in the poor metabolizers and 11.1 hours in the extensive metabolizers. Syncope occurred in one (11%) of the CYP450 2C19 poor metabolizers and none of the extensive metabolizers. Flibanserin AUC in this subject was 3.2 fold higher than in the CYP450 2C19 extensive metabolizers.

MANAGEMENT: Caution is advised when flibanserin is used with CYP450 2C19 inhibitors. Patients should be monitored for signs and symptoms of hypotension, syncope, and central nervous system depression.

Addyi

Generic Name: flibanserin

Brand name: Addyi

Synonyms: n.a.

What is Addyi?

Prozac Weekly

Generic Name: fluoxetine

Brand name: Prozac, Prozac Weekly, Sarafem, PROzac Pulvules, Rapiflux, Selfemra

Synonyms: n.a.

What is Prozac Weekly?