Adempas and Alka-Seltzer Heartburn + Gas

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Taking the riociguat and calcium carbonate doses too close together may interfere with the absorption of riociguat and reduce its effectiveness. To prevent or minimize the interaction, avoid taking calcium carbonate or other antacid-containing medications within one hour of taking riociguat. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Concurrent administration of riociguat with antacids may reduce its gastrointestinal absorption. Riociguat exhibits pH-dependent solubility, with increased solubility at lower pH. According to the product labeling, administration of riociguat with an antacid containing aluminum hydroxide and magnesium hydroxide resulted in decreases of riociguat peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 50% and 30%, respectively. The Cmax and AUC of the active metabolite, M1, which has 1/3 to 1/10 the pharmacologic activity of riociguat, were similarly reduced.

MANAGEMENT: Antacids should not be taken within 1 hour of riociguat administration.

Adempas

Generic Name: riociguat

Brand name: Adempas

Synonyms: n.a.

What is Adempas?

Alka-Seltzer Heartburn + Gas

Generic Name: calcium carbonate / simethicone

Brand name: Alka-Seltzer Heartburn + Gas, Gas-X with Maalox Extra Strength, Maalox Advanced Maximum Strength, Maalox Junior Plus Antigas, Tums Gas Relief Chewy Bites

Synonyms: n.a.

What is Alka-Seltzer Heartburn + Gas?