Adempas and Aluminum Hydroxide and Magnesium Carbonate Chewable Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Taking the riociguat and aluminum hydroxide doses too close together may interfere with the absorption of riociguat and reduce its effectiveness. To prevent or minimize the interaction, avoid taking aluminum hydroxide or other antacid-containing medications within one hour of taking riociguat. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Concurrent administration of riociguat with antacids may reduce its gastrointestinal absorption. Riociguat exhibits pH-dependent solubility, with increased solubility at lower pH. According to the product labeling, administration of riociguat with an antacid containing aluminum hydroxide and magnesium hydroxide resulted in decreases of riociguat peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 50% and 30%, respectively. The Cmax and AUC of the active metabolite, M1, which has 1/3 to 1/10 the pharmacologic activity of riociguat, were similarly reduced.

MANAGEMENT: Antacids should not be taken within 1 hour of riociguat administration.

Adempas

Generic Name: riociguat

Brand name: Adempas

Synonyms: n.a.

What is Adempas?

Aluminum Hydroxide and Magnesium Carbonate Chewable Tablets

Generic Name: aluminum hydroxide / magnesium carbonate

Brand name: Gaviscon Extra Relief Formula, Acid Gone, Gaviscon

Synonyms: n.a.

What is Aluminum Hydroxide and Magnesium Carbonate Chewable Tablets?