Adempas and Esomeprazole Delayed-Release Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Esomeprazole may reduce the blood levels and effects of riociguat. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of riociguat with proton pump inhibitors may reduce its gastrointestinal absorption. Riociguat exhibits pH-dependent solubility, with increased solubility at lower pH. According to the product labeling, administration of riociguat with omeprazole resulted in decreases of riociguat peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 30% and 25%, respectively. The Cmax and AUC of the active metabolite, M1, which has 1/3 to 1/10 the pharmacologic activity of riociguat, were not significantly affected.

MANAGEMENT: No dosage adjustment for riociguat is recommended when coadministered with proton pump inhibitors. However, patients should be monitored for potentially diminished therapeutic effects of riociguat.

Adempas

Generic Name: riociguat

Brand name: Adempas

Synonyms: n.a.

What is Adempas?

Esomeprazole Delayed-Release Tablets

Generic Name: esomeprazole

Brand name: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV

Synonyms: Esomeprazole

What is Esomeprazole Delayed-Release Tablets?