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Adempas and Gefitinib Oral

Determining the interaction of Adempas and Gefitinib Oral and the possibility of their joint administration.

Check result:

Adempas <> Gefitinib Oral

Relevance: 02.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Gefitinib may increase the blood levels and effects of riociguat. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with potent inhibitors of CYP450 1A1 may theoretically increase the plasma concentrations of riociguat, which is partially metabolized by the isoenzyme to its main active metabolite (1/10th to 1/3rd the pharmacologic activity of riociguat). Increased levels of riociguat may increase the risk for hypotension.

MANAGEMENT: Caution is advised if riociguat is prescribed in combination with a potent inhibitor of CYP450 1A1. Blood pressure should be monitored, and a dose reduction of riociguat should be considered if necessary.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Adempas

Generic Name: riociguat

Brand name: Adempas

Synonyms: n.a.

What is Adempas?

Gefitinib Oral

Generic Name: gefitinib

Brand name: Iressa

Synonyms: Gefitinib

What is Gefitinib Oral?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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