Adempas and Nitro-Time

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using riociguat together with nitroglycerin is not recommended. These medications work by dilating the blood vessels, and combining them may cause excessively low blood pressure, fainting, and chest pain. You may also be more likely to experience side effects such as dizziness, lightheadedness, fainting, flushing, headache, and nasal congestion. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration of riociguat with organic nitrates or nitric oxide donors may cause significant hypotension, syncope, and myocardial ischemia. Riociguat stimulates soluble guanylate cyclase (sGC), an enzyme in the cardiopulmonary system that binds with nitric oxide (NO) to catalyze the synthesis of cyclic guanosine monophosphate (cGMP). The resultant accumulation of cGMP in vascular smooth muscle cells leads to peripheral vasodilation. In study subjects, sublingual nitroglycerin (0.4 mg) administered 4 and 8 hours after riociguat (2.5 mg) led to increased blood pressure reductions, and syncope was reported in some.

MANAGEMENT: Concomitant use of riociguat with organic nitrates (e.g., nitroglycerin) or nitric oxide donors (e.g., amyl nitrite) in any form is considered contraindicated.

Adempas

Generic Name: riociguat

Brand name: Adempas

Synonyms: n.a.

What is Adempas?

Nitro-Time

Generic Name: nitroglycerin

Brand name: Nitro-Time, Gonitro, Nitrolingual, NitroMist, Nitrostat, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: n.a.

What is Nitro-Time?