Adempas and Sodium bicarbonate Oral, Intravenous, Subcutaneous
Determining the interaction of Adempas and Sodium bicarbonate Oral, Intravenous, Subcutaneous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Taking the riociguat and sodium bicarbonate doses too close together may interfere with the absorption of riociguat and reduce its effectiveness. To prevent or minimize the interaction, avoid taking sodium bicarbonate or other antacid-containing medications within one hour of taking riociguat. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Concurrent administration of riociguat with antacids may reduce its gastrointestinal absorption. Riociguat exhibits pH-dependent solubility, with increased solubility at lower pH. According to the product labeling, administration of riociguat with an antacid containing aluminum hydroxide and magnesium hydroxide resulted in decreases of riociguat peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 50% and 30%, respectively. The Cmax and AUC of the active metabolite, M1, which has 1/3 to 1/10 the pharmacologic activity of riociguat, were similarly reduced.
MANAGEMENT: Antacids should not be taken within 1 hour of riociguat administration.
- "Product Information. Adempas (riociguat)." Bayer Pharmaceutical Inc, West Haven, CT.
Generic Name: sodium bicarbonate
Brand name: Neut
Synonyms: Sodium bicarbonate, Sodium Bicarbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Adempas-Sodium Bicarbonate Tablets
- Adempas-Sodium Bicarbonate, Citric Acid, and Simethicone Effervescent Granule Pkt
- Adempas-Sodium biphosphate and sodium phosphate
- Adempas-Sodium biphosphate and sodium phosphate rectal
- Adempas-Sodium cellulose phosphate
- Adempas-Sodium chloride
- Sodium bicarbonate Oral, Intravenous, Subcutaneous-Adempas Tablets
- Sodium bicarbonate Oral, Intravenous, Subcutaneous-Adenocard
- Sodium bicarbonate Oral, Intravenous, Subcutaneous-Adenoscan
- Sodium bicarbonate Oral, Intravenous, Subcutaneous-Adenosine
- Sodium bicarbonate Oral, Intravenous, Subcutaneous-Adenosine Intravenous
- Sodium bicarbonate Oral, Intravenous, Subcutaneous-Adenovirus Type 4 and Type 7 Vaccine Live Oral