Adempas and Up and Up Acid Controller Complete
Determining the interaction of Adempas and Up and Up Acid Controller Complete and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Taking the riociguat and calcium carbonate doses too close together may interfere with the absorption of riociguat and reduce its effectiveness. To prevent or minimize the interaction, avoid taking calcium carbonate or other antacid-containing medications within one hour of taking riociguat. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Concurrent administration of riociguat with antacids may reduce its gastrointestinal absorption. Riociguat exhibits pH-dependent solubility, with increased solubility at lower pH. According to the product labeling, administration of riociguat with an antacid containing aluminum hydroxide and magnesium hydroxide resulted in decreases of riociguat peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 50% and 30%, respectively. The Cmax and AUC of the active metabolite, M1, which has 1/3 to 1/10 the pharmacologic activity of riociguat, were similarly reduced.
MANAGEMENT: Antacids should not be taken within 1 hour of riociguat administration.
- "Product Information. Adempas (riociguat)." Bayer Pharmaceutical Inc, West Haven, CT.
Generic Name: calcium carbonate / famotidine / magnesium hydroxide
Brand name: Dual Action Complete, Duo Fusion, Pepcid Complete
Synonyms: Berkley and Jensen Acid Controller Complete
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Adempas-Up and Up Acid Reducer
- Adempas-Up and Up All Day Allergy Relief
- Adempas-Up and Up All Day Allergy Relief D
- Adempas-Up and Up Anti-Diarrheal Solution
- Adempas-Up and Up Childrens All Day Allergy Relief
- Adempas-Up and Up Migraine Relief
- Up and Up Acid Controller Complete-Adempas Tablets
- Up and Up Acid Controller Complete-Adenocard
- Up and Up Acid Controller Complete-Adenoscan
- Up and Up Acid Controller Complete-Adenosine
- Up and Up Acid Controller Complete-Adenosine Intravenous
- Up and Up Acid Controller Complete-Adenovirus Type 4 and Type 7 Vaccine Live Oral