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Adempas Tablets and Neut

Determining the interaction of Adempas Tablets and Neut and the possibility of their joint administration.

Check result:

Adempas Tablets <> Neut

Relevance: 14.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Taking the riociguat and sodium bicarbonate doses too close together may interfere with the absorption of riociguat and reduce its effectiveness. To prevent or minimize the interaction, avoid taking sodium bicarbonate or other antacid-containing medications within one hour of taking riociguat. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Concurrent administration of riociguat with antacids may reduce its gastrointestinal absorption. Riociguat exhibits pH-dependent solubility, with increased solubility at lower pH. According to the product labeling, administration of riociguat with an antacid containing aluminum hydroxide and magnesium hydroxide resulted in decreases of riociguat peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 50% and 30%, respectively. The Cmax and AUC of the active metabolite, M1, which has 1/3 to 1/10 the pharmacologic activity of riociguat, were similarly reduced.

MANAGEMENT: Antacids should not be taken within 1 hour of riociguat administration.

References

"Product Information. Adempas (riociguat)." Bayer Pharmaceutical Inc, West Haven, CT.

Adempas Tablets

Generic Name: riociguat

Brand name: Adempas

Synonyms: Riociguat

What is Adempas Tablets?

Neut

Generic Name: sodium bicarbonate

Brand name: Neut

Synonyms: Neut Injection

What is Neut?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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