Adenoscan and Aspirin and Dipyridamole Capsules
Determining the interaction of Adenoscan and Aspirin and Dipyridamole Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using adenosine together with dipyridamole can increase the levels of dipyridamole and can affect the rhythm of your heart. This can lead to facial flushing, chest pressure or discomfort, headache, lightheadedness, and shortness of breath. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Dipyridamole potentiates the effects of adenosine. The mechanism probably is inhibition of endogenous and exogenous adenosine reuptake, which increases plasma concentrations of adenosine. Severe symptomatic bradycardia and sinus arrest was reported in a 79-year-old patient who had taken her last dose of dipyridamole-aspirin 12 hours before an adenosine heart scan.
MANAGEMENT: The manufacturer recommends discontinuing dipyridamole for 24 hours before administering adenosine. If this is not feasible, reductions in adenosine dosage are recommended. Some experts have suggested that only 25% to 50% of the normal dose is needed to control supraventricular tachycardia.
- Littmann L, Anderson JD, Monroe MH "Adenosine and Aggrenox: a hazardous combination." Ann Intern Med 137 (2002): W1
- Watt AH, Bernard MS, Webster J, Passani SL, Stephens MR, Routledge PA "Intravenous adenosine in the treatment of supraventricular tachycardia: a dose-ranging study and interaction with dipyridamole." Br J Clin Pharmacol 21 (1986): 227-30
- Mader TJ "Adenosine: adverse interactions." Ann Emerg Med 21 (1992): 453
- Conti CR "Adenosine: clinical pharmacology and applications." Clin Cardiol 14 (1991): 91-3
- Bergmann SR "Alert to physicians: Possible interaction of Aggrenox and adenosine." J Am Coll Cardiol 36 (2000): 1432
- Biaggioni I, Onrot J, Hollister AS, Robertson D "Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole." Life Sci 39 (1986): 2229-36
- McCollam PL, Uber WE, Van Bakel AB "Adenosine-related ventricular asystole ." Ann Intern Med 118 (1993): 315-6
Generic Name: adenosine
Brand name: Adenocard, Adenoscan, Adeno-jec, My-O-Den, Myoden
Synonyms: n.a.
Generic Name: aspirin / dipyridamole
Brand name: Aggrenox
Synonyms: Aspirin and dipyridamole, Aspirin and Dipyridamole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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