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Adenoscan and Digoxin Intravenous

Determining the interaction of Adenoscan and Digoxin Intravenous and the possibility of their joint administration.

Check result:
Adenoscan <> Digoxin Intravenous
Relevance: 23.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before getting treatment with adenosine, let your doctor know if you are currently using digoxin. Combining these medications can increase the risk of an irregular heart rhythm that may be serious. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: The use of adenosine in patients receiving digitalis glycosides may increase the risk of ventricular fibrillation. Rare cases of ventricular fibrillation, including both resuscitated and fatal cases, have been reported following treatment with adenosine intravenous bolus injection for the rapid conversion of paroxysmal supraventricular tachycardias to a normal sinus rhythm. Most cases were associated with the concomitant use of digoxin or, less frequently, digoxin and verapamil. However, no causal relationship or drug-drug interaction has been established. Concomitant use of adenosine and digitalis glycosides may also increase the risk and/or severity of sinus bradycardia and heart block due to additive or synergistic depressant effects on the sinoatrial and atrioventricular nodes.

MANAGEMENT: Adenosine should be used with caution in patients receiving digitalis glycosides. Adenosine should be discontinued immediately if angina, severe bradycardia, severe hypotension, or asystole occurs. Also, patients who develop high-level atrioventricular block on one dose of adenosine should not be given additional doses. Appropriate resuscitative measures should be readily available.

References
  • Ben-Sorek ES, Wiesel J "Ventricular fibrillation following adenosine administration. A case report." Arch Intern Med 153 (1993): 2701-2
  • Mulla N, Karpawich PP "Ventricular fibrillation following adenosine therapy for supraventricular tachycardia in a neonate with concealed wolff-parkinson-white syndrome treated with digoxin." Pediatr Emerg Care 11 (1995): 238-9
  • "Product Information. Adenocard (adenosine)." Fujisawa, Deerfield, IL.
  • Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10
Adenoscan

Generic Name: adenosine

Brand name: Adenocard, Adenoscan, Adeno-jec, My-O-Den, Myoden

Synonyms: n.a.

Digoxin Intravenous

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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