Adenoscan and Lefamulin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR CLOSELY: Adenosine has induced torsade de pointes arrhythmia in patients with preexisting long QT syndrome. Theoretically, coadministration of adenosine with agents that can prolong the QT interval may increase that risk as well. The mechanism has not been established, but may involve the depressant effect of adenosine on the sinoatrial and atrioventricular nodes. Rare cases of severe bradycardia have been reported during treatment with adenosine, which could favor the occurrence of torsade de pointes, especially in patients with prolonged QT intervals. Interestingly, no case of torsade de pointes has been reported when adenosine is given by continuous infusion. MANAGEMENT: Adenosine should be used with caution in patients receiving drugs that are known to prolong the QT interval. Adenosine should be discontinued immediately if severe bradycardia occurs. References Drescher MJ, Mendelssohn R "Transient torsades de pointes after adenosine." Isr J Trauma Intensive Care Emerg Med 2 (2002): 15-7 Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6 Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7 Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10 Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301 Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422 Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 View all 8 references

MONITOR CLOSELY: Adenosine has induced torsade de pointes arrhythmia in patients with preexisting long QT syndrome. Theoretically, coadministration of adenosine with agents that can prolong the QT interval may increase that risk as well. The mechanism has not been established, but may involve the depressant effect of adenosine on the sinoatrial and atrioventricular nodes. Rare cases of severe bradycardia have been reported during treatment with adenosine, which could favor the occurrence of torsade de pointes, especially in patients with prolonged QT intervals. Interestingly, no case of torsade de pointes has been reported when adenosine is given by continuous infusion.

MANAGEMENT: Adenosine should be used with caution in patients receiving drugs that are known to prolong the QT interval. Adenosine should be discontinued immediately if severe bradycardia occurs.

Adenoscan

Generic Name: adenosine

Brand name: Adenocard, Adenoscan, Adeno-jec, My-O-Den, Myoden

Synonyms: n.a.

What is Adenoscan?

Lefamulin

Generic Name: lefamulin

Brand name: Xenleta

Synonyms: Lefamulin (oral/injection)

What is Lefamulin?