Adlyxin and Jantoven
Determining the interaction of Adlyxin and Jantoven and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration of a single 25 mg dose of warfarin with daily dosing of lixisenatide 20 mcg resulted in a 19% decrease in warfarin peak plasma concentration (Cmax) and a 7-hour delay in time to reach peak plasma concentration (Tmax), but had no effect on warfarin systemic exposure (AUC) or the International Normalized Ratio (INR). The mechanism of interaction may involve delayed absorption due to slowing of the gastric emptying rate by lixisenatide. Based on these observations, no dosage adjustment for warfarin is required when coadministered with lixisenatide. The interaction has not been studied with other oral vitamin K antagonists.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Adlyxin (lixisenatide)." sanofi-aventis, Bridgewater, NJ.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Adlyxin-Janumet
- Adlyxin-Janumet XR
- Adlyxin-Januvia
- Adlyxin-Japanese Encephalitis Vaccine
- Adlyxin-Japanese Encephalitis Virus Vaccine (Inactivated)
- Adlyxin-Japanese encephalitis virus vaccine SA14-14-2
- Jantoven-Adlyxin Starter Pack
- Jantoven-Admelog
- Jantoven-Admelog (Insulin Lispro (U-100) Cartridges and Pens)
- Jantoven-Admelog (Insulin Lispro (U-100) Vials)
- Jantoven-Ado-trastuzumab emtansine
- Jantoven-Ado-trastuzumab emtansine Intravenous