Ado-trastuzumab emtansine and Aspirin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ado-trastuzumab emtansine together with aspirin may increase the risk of bleeding, including severe and sometimes fatal hemorrhage. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Coadministration of trastuzumab emtansine with anticoagulant or antiplatelet drugs may potentiate the risk of hemorrhagic events associated with these drugs. In clinical trials, fatal cases of hemorrhage occurred in patients receiving trastuzumab emtansine in addition to anticoagulant and antiplatelet therapy.

MANAGEMENT: Caution is recommended and additional monitoring should be considered if trastuzumab emtansine must be used with anticoagulant or antiplatelet drugs. In general, monitoring of platelet counts is recommended prior to each dose of trastuzumab emtansine. If platelet counts decrease to less than 50,000/mm3 (Grade 3 or higher), discontinue trastuzumab emtansine until platelet counts increase to 75,000/mm3 or higher (Grade 1 or less).

Ado-trastuzumab emtansine

Generic Name: ado-trastuzumab emtansine

Brand name: Kadcyla

Synonyms: Ado-Trastuzumab Emtansine

What is Ado-trastuzumab emtansine?

Aspirin

Generic Name: aspirin

Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult

Synonyms: n.a.

What is Aspirin?