Ado-trastuzumab emtansine and Bismuth Subcitrate, Metronidazole, and Tetracycline
Determining the interaction of Ado-trastuzumab emtansine and Bismuth Subcitrate, Metronidazole, and Tetracycline and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using bismuth subcitrate potassium together with tetracycline may decrease the effects of tetracycline. Administration of tetracycline and bismuth subcitrate potassium should be separated by two to three hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Administration of a bismuth-containing preparation within two to three hours of a tetracycline may significantly decrease serum tetracycline concentrations. Data are available for tetracycline and doxycycline. The proposed mechanism is chelation of tetracycline by bismuth.
MANAGEMENT: Administration of a tetracycline and bismuth-containing preparation should be separated by two to three hours. Patients should be monitored for diminished tetracycline efficacy.
- "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc., Boston, MA.
- Albert KS, Welch RD, DeSante KA, DiSanto AR "Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture." J Pharm Sci 68 (1979): 586-8
- Ericsson CD, Feldman S, Pickering LK, Cleary TG "Influence of subsalicylate bismuth on absorption of doxycycline." JAMA 247 (1982): 2266-7
- "Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA.
Generic Name: ado-trastuzumab emtansine
Brand name: Kadcyla
Synonyms: Ado-Trastuzumab Emtansine
Generic Name: bismuth subcitrate potassium / metronidazole / tetracycline
Brand name: Pylera
Synonyms: Bismuth subcitrate potassium, metronidazole, and tetracycline
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ado-trastuzumab emtansine-Bismuth Subgallate
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- Ado-trastuzumab emtansine-Bismuth Subsalicylate Suspension
- Ado-trastuzumab emtansine-Bismuth Subsalicylate Tablets
- Ado-trastuzumab emtansine-Bismuth subsalicylate, metronidazole, and tetracycline
- Bismuth Subcitrate, Metronidazole, and Tetracycline-Ado-trastuzumab emtansine Intravenous
- Bismuth Subcitrate, Metronidazole, and Tetracycline-Adox Pak 2/100
- Bismuth Subcitrate, Metronidazole, and Tetracycline-Adoxa
- Bismuth Subcitrate, Metronidazole, and Tetracycline-Adoxa CK
- Bismuth Subcitrate, Metronidazole, and Tetracycline-Adoxa Pak
- Bismuth Subcitrate, Metronidazole, and Tetracycline-Adoxa Pak 1/100