Adox Pak 2/100 and Potassium Bicarbonate and Potassium Citrate
Determining the interaction of Adox Pak 2/100 and Potassium Bicarbonate and Potassium Citrate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using potassium citrate together with doxycycline may decrease the effects of doxycycline. Administration of potassium citrate and doxycycline should be separated by three to four hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve increased renal elimination of tetracyclines when the urine becomes alkalinized. Information is available for doxycycline, tetracycline, and sodium bicarbonate only.
MANAGEMENT: If these drugs must be used together, an alternating dosing schedule is recommended (three to four hours apart).
- Elliott GR "Sodium bicarbonate and oral tetracycline." Clin Pharmacol Ther 13 (1972): 459
- Jaffe JM, Colaizzi JI, Poust RI, McDonald RH Jr "Effect of altered urinary pH on tetracycline and doxycycline excretion in humans." J Pharmacokinet Biopharm 1 (1973): 267-82
- Jaffe JM, Poust RI, Feld SL, Colaizzi JL "Influence of repetitive dosing and altered urinary pH on doxycycline excretion in humans." J Pharm Sci 63 (1974): 1256-60
Generic Name: doxycycline
Brand name: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, TargaDOX, Vibramycin, Doxy 100, TargaDOX
Synonyms: Doxycycline
Generic Name: potassium bicarbonate / potassium citrate
Brand name: Effervescent Potassium, K-Effervescent, K-vescent, K-vescent, K+Care ET, Klor-Con/EF, Effer-K, K-Prime
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Adox Pak 2/100-Potassium Bicarbonate Capsules and Tablets
- Adox Pak 2/100-Potassium Chloride
- Adox Pak 2/100-Potassium Chloride and Dextrose
- Adox Pak 2/100-Potassium chloride and sodium chloride
- Adox Pak 2/100-Potassium Chloride Capsules
- Adox Pak 2/100-Potassium Chloride Extended-Release Capsules
- Potassium Bicarbonate and Potassium Citrate-Adoxa
- Potassium Bicarbonate and Potassium Citrate-Adoxa CK
- Potassium Bicarbonate and Potassium Citrate-Adoxa Pak
- Potassium Bicarbonate and Potassium Citrate-Adoxa Pak 1/100
- Potassium Bicarbonate and Potassium Citrate-Adoxa Pak 1/150
- Potassium Bicarbonate and Potassium Citrate-Adoxa TT