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Adoxa Pak 1/150 and Nafcil

Determining the interaction of Adoxa Pak 1/150 and Nafcil and the possibility of their joint administration.

Check result:

Adoxa Pak 1/150 <> Nafcil

Relevance: 09.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using doxycycline together with penicillin V potassium. Combining these medications may reduce the effectiveness of penicillin V potassium. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by penicillins. Antagonism is more likely when low doses of either agent are administered. Therapeutic failure may result.

MANAGEMENT: This combination should be avoided if possible.

References

"Product Information. Declomycin (demeclocycline)." Lederle Laboratories, Wayne, NJ.
"Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA.
Olsson RA, Kirby JC, Romansky MJ "Pneumococcal meningitis in the adult." Ann Intern Med 55 (1961): 545-9
Jawetz E "Synergism and antagonism among antimicrobial drugs: a personal perspective." West J Med 123 (1975): 87-91
Lepper MH, Dowling HF "Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin." Arch Intern Med 88 (1951): 489-94
Gunnison JB, Coleman VR, Jawetz E "Interference of aureomycin and of terramycin with action of penicillin in vitro." Proc Soc Exp Biol Med 75 (1950): 549-52

Adoxa Pak 1/150

Generic Name: doxycycline

Brand name: Acticlate, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, Monodox, Morgidox, Oraxyl, TargaDOX, Vibramycin, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Oracea, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Doxy 100, TargaDOX

Synonyms: Adoxa Pak 1/100

What is Adoxa Pak 1/150?

Nafcil

Generic Name: penicillin v potassium

Brand name: PC Pen VK, Pen-V, Penicillin-VK, Veetids

Synonyms: Penicillin, Penicillin V Potassium

What is Nafcil?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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