Adoxa TT and Coumadin Injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Doxycycline may increase the blood-thinning effects of warfarin in some patients. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring of your INR to safely use both medications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Tetracyclines may increase the hypoprothrombinemic effects of warfarin and similar anticoagulants. The mechanism of interaction has not been established, but may involve depression of plasma prothrombin activity or suppression of vitamin K-producing bacteria in the gastrointestinal tract, although the latter may be of limited clinical importance except in patients whose dietary intake of vitamin K is severely reduced. There have been case reports of bruising, hematomas, and bleeding in association with increased prothrombin times or INRs in patients stabilized on warfarin and other coumarins several days to weeks following the addition of a tetracycline antibiotic. An early study from 1962 reported that 6 out of 9 anticoagulant patients had a significant fall in their prothrombin-proconvertin concentration when treated with chlortetracycline 250 mg four times daily for 4 days. In a population-based cohort study of 1124 patients receiving acenocoumarol or phenprocoumon over a 7.75-year period, Dutch investigators found that doxycyline use increased the risk of overanticoagulation (defined as INR >=6.0) with an adjusted relative risk of 4.3, and that the risk was most strongly increased 4 or more days after start of doxycycline. In subsequent cohort studies, the same group of investigators also reported that the relative risk of hospitalization for bleeding was increased in patients receiving acenocoumarol or phenprocoumon concomitantly with doxycycline or tetracycline.

MANAGEMENT: Caution is advised when warfarin and similar anticoagulants are used with tetracyclines. The INR should be checked frequently and the anticoagulant dosage adjusted accordingly, particularly following initiation or discontinuation of tetracycline therapy in patients who are stabilized on their anticoagulant regimen. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

Adoxa TT

Generic Name: doxycycline

Brand name: Acticlate, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, Monodox, Morgidox, Oraxyl, TargaDOX, Vibramycin, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Oracea, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Doxy 100, TargaDOX

Synonyms: Adoxa TT (Oral)

What is Adoxa TT?

Coumadin Injection

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: Coumadin

What is Coumadin Injection?