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AdreView and Phenylephrine and Guaifenesin Drops

Determining the interaction of AdreView and Phenylephrine and Guaifenesin Drops and the possibility of their joint administration.

Check result:

AdreView <> Phenylephrine and Guaifenesin Drops

Relevance: 10.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Phenylephrine may interfere with imaging studies done with iobenguane I-123. Let your doctor know you are receiving or have recently received phenylephrine if you are scheduled for an imaging procedure to detect pheochromocytoma or neuroblastoma (tumors in the nervous system). You may need to stop using phenylephrine for a certain amount of time before having the procedure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with drugs that block norepinephrine uptake or deplete norepinephrine stores may decrease iobenguane I-123 uptake in neuroendocrine tumors and lead to false-negative imaging results. Since iobenguane I-123 is subject to the same uptake and accumulation pathways as norepinephrine, drugs that alter norepinephrine disposition in adrenergic nerve terminals and presynaptic storage vesicles will likewise affect iobenguane. These drugs include antihypertensive agents that deplete norepinephrine stores or inhibit reuptake (e.g., guanethidine, reserpine, labetalol); antidepressants that inhibit norepinephrine transporter function (e.g., tricyclic antidepressants, selective serotonin reuptake inhibitors); sympathomimetic amines (e.g., phenylephrine, phenylpropanolamine, pseudoephedrine, ephedrine); central nervous stimulants (e.g., amphetamines); phenothiazines; and cocaine. Clinical studies have not determined which specific drugs may cause false-negative imaging results and whether all drugs in a specific pharmacologic class have the same potential to produce negative imaging results. Increasing the dose of iobenguane I-123 will not overcome any potential effect of these drugs.

MANAGEMENT: When medically feasible, any drug that blocks norepinephrine uptake or deplete norepinephrine stores should be discontinued for at least five biological half-lives before iobenguane I-123 administration. Patients should be monitored for the occurrence of clinically significant withdrawal symptoms, especially patients with elevated levels of circulating catecholamines and their metabolites.

References

"Product Information. AdreView (iobenguane I-123)." GE Healthcare, Princeton, NJ.

AdreView

Generic Name: iobenguane I 123

Brand name: AdreView

Synonyms: n.a.

What is AdreView?

Phenylephrine and Guaifenesin Drops

Generic Name: guaifenesin / phenylephrine

Brand name: Aldex G, Aquatab D, Deconex, Deconex IR, Donatussin Drops, D-Phen 1000, Duravent PE, Gilphex TR, Liquibid-PD, MucaphEd, Nariz, Prolex D, Sudafed PE Non-Drying Sinus, Supress-PE, Triaminic Chest & Nasal Congestion, Xpect-PE, Sinupan, Deconsal Pediatric, Efasin, Amidal, Chemdal, Quindal, Endal, Liquibid-D, Rescon-GG, SINUvent PE, Entex LA, Entex, Crantex, Crantex LA Capsules, Amitex LA, Entex ER, Duraphen II, Crantex ER, Liquibid-D 1200, Phenavent LA, Phenavent D, Sina-12X, Deconsal II, Guaifed Caps, Guaifed PD, Phenavent, Tussbid, Phenavent PED, Nescon-PD, Pendex, Prolex PD, Aldex, Nasex, Crantex LA Tablets, Duratuss, Duratuss GP, Lusonex, Sitrex, Guaiphen-PD, Wellbid-D, Wellbid-D 1200, Despec, Xedec, Nasex-G, Gentex LA, Guaiphen-D 600, Guaiphen-D 1200, Simuc, Zotex GPX, Duomax, Guaifen PE, Norel EX, Nexphen PD, Respa-PE, Reluri, Duraphen 1000, Dynex LA, Sudex, Extendryl G, Maxiphen, Ambi 40/1000, MontePhen, Xedec II, Simuc-GP, Duratuss PE, Sitrex PD, Refenesen PE, Mydex, Medent-PE, Genexa LA, Nazarin, J-Max, Mucus Relief Sinus, Robitussin Head & Chest Congestion, Visonex, Zyrphen, PE-Guai, Guiadex PD, D-Tab, ExeTuss, ExeTuss-GP, Mucinex Children's Cold, Quintex, Guiatex PE, Fenesin PE IR, Medent-PEI, Liquibid PD-R, Liquibid D-R, Zoden Drops, Entex LQ, Tussi-Pres PE, Lusair, Reese Onetab Congestion & Cough, ED Bron GP, Relcof IR, Giltuss Sinus & Congestion, Zotex-GP

Synonyms: Guaifenesin and phenylephrine, Guaifenesin and Phenylephrine

What is Phenylephrine and Guaifenesin Drops?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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