Adriamycin and Cytoxan (Cyclophosphamide Tablets)
Determining the interaction of Adriamycin and Cytoxan (Cyclophosphamide Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:A single case report suggests that doxorubicin may enhance the risk of hemorrhagic cystitis associated with cyclophosphamide. Animal data have shown that cyclophosphamide can decrease the formation of inactive metabolites of doxorubicin. The clinical relevance of these data is unknown, and more data are needed.
- Ershler WB, Gilchrist KW, Citrin DL "Adriamycin enhancement of cyclophoshamide-induced bladder injury." J Urol 123 (1980): 121-2
- Dodion P, Akman SR, Tamburini JM, Riggs CE Jr, Colvin OM, Bachur NR "Interactions between cyclophosphamide and doxorubicin metabolism in rats. II. Effect of cyclophosphamide on the aldoketoreductase system." J Pharmacol Exp Ther 237 (1986): 271-4
Generic Name: doxorubicin
Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS
Synonyms: n.a.
Generic Name: cyclophosphamide
Brand name: Cytoxan, Neosar, Cytoxan Lyophilized
Synonyms: Cytoxan (Injection), Cytoxan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Adriamycin-Cytoxan Lyophilized
- Adriamycin-Cytra K Oral Solution
- Adriamycin-Cytra-2
- Adriamycin-Cytra-2 Oral Solution
- Adriamycin-Cytra-3
- Adriamycin-Cytra-3 Oral Syrup
- Cytoxan (Cyclophosphamide Tablets)-Adrucil
- Cytoxan (Cyclophosphamide Tablets)-Adrucil injection
- Cytoxan (Cyclophosphamide Tablets)-Advair
- Cytoxan (Cyclophosphamide Tablets)-Advair Diskus
- Cytoxan (Cyclophosphamide Tablets)-Advair Diskus 100/50
- Cytoxan (Cyclophosphamide Tablets)-Advair Diskus 250/50