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Adrucil and Cimetidine Tablets

Determining the interaction of Adrucil and Cimetidine Tablets and the possibility of their joint administration.

Check result:

Adrucil <> Cimetidine Tablets

Relevance: 04.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Chronic administration of cimetidine may increase 5-fluorouracil serum concentrations and antineoplastic effectiveness. The mechanism is unknown. The results of some studies have suggested that this interaction may have beneficial effects in certain patients with colorectal cancer.

References

Eaton D, Hawkins RE "Cimetidine in colorectal cancer--are the effects immunological or adhesion-mediated?" Br J Cancer 86 (2002): 159-60
Matsumoto S, Imaeda Y, Umemoto S, Kobayashi K, Suzuki H, Okamoto T "Cimentidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells." Br J Cancer 86 (2002): 161-7
Harvey VJ, Slevin ML, Dilloway MR, Clark PI, Johnston A, Lant AF "The influence of cimetidine on the pharmacokinetics of 5-fluorouracil." Br J Clin Pharmacol 18 (1984): 421-30

Adrucil

Generic Name: fluorouracil

Brand name: Adrucil

Synonyms: Adrucil (injection)

What is Adrucil?

Cimetidine Tablets

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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